CCNL1 Antibody
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中文名稱：CCNL1兔多克隆抗體
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貨號：CSB-PA986857
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規格：￥2024
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圖片：
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cyclin-L1 antibody. -
Western blot analysis of extracts from HepG2 cells, using Cyclin-L1 antibody. -
Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using Cyclin-L1 antiobdy. The lane on the left is treated with systhesized peptide.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CCNL1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human Cyclin-L1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).
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基因功能參考文獻：
- Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms influence the development of diabetic retinopathy (DR). PMID: 27607899
- CCNL1 is the target gene of miR-199b-5p. PMID: 26043836
- Data indicate that if the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. PMID: 22685556
- birth weight lowering effect of the C-allele of rs900400 located near LEKR1 and CCNL1 was replicated in the Danish population. Furthermore the C-allele was associated with increased insulin response following oral glucose stimulation PMID: 22073261
- Data show low birth weight in Asian Indians is not due to variation near CCNL1/ADCY5, but variant ADCY5 is associated with elevated glucose/decreased insulin response which suggests a common genetic cause of low birth weight and risk of type 2 diabetes. PMID: 21712988
- These data demonstrate that there is a fine balance between CCNL1 and TIMP1, which may contribute to breast cancer development. PMID: 21586274
- Our results suggest that a genetic variant of ccnl1 leads to symmetric growth restriction from early pregnancy onward PMID: 21307140
- Cyclin L1 amplification is associated with uterine cervical carcinoma. PMID: 20721974
- variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight PMID: 20372150
- role in pre-mRNA splicing PMID: 11980906
- Our results indicate that CCNL1 plays a critical role in the loco-regional progression of HNSCC and may serve as an indicator for occult advanced tumour stages. PMID: 15700036
- study suggests that cyclin l1 may have a role in RNA processing complex anc ould participate in tumor progression of head and neck squamous cell carcinoma PMID: 16598186
- Data show that a green fluorescent protein (GFP) fusion protein of cyclin L1, in contrast to cyclin L2, was not mobile within the nucleus of living COS7 cells. PMID: 17494991
- CDK11(p110) interacts physically and functionally with cyclin Lalpha and -beta isoforms and SR proteins to regulate splicing. PMID: 18216018
- Cyclin L has been shown to associate with the PITSLRE kinase and is involved in pre-mRNA processing. PMID: 11980906
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亞細胞定位：Nucleus speckle. Nucleus, nucleoplasm.
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蛋白家族：Cyclin family, Cyclin L subfamily
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組織特異性：Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
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數據庫鏈接：
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