CCNB2 Antibody

中文名稱：

CCNB2兔多克隆抗體
貨號：

CSB-PA004808LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: CCNB2 antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa

Immunofluorescence staining of Hela cells with CSB-PA004808LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CCNB2 Polyclonal antibody
Uniprot No.：

O95067
基因名：

CCNB2
別名：

ccnb2 antibody; CCNB2_HUMAN antibody; CycB2 antibody; Cyclin B2 antibody; G2 mitotic specific cyclin B2 antibody; G2/mitotic specific cyclin B2 antibody; G2/mitotic-specific cyclin-B2 antibody; HsT17299 antibody; MGC108931 antibody; MGC140694 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human G2/mitotic-specific cyclin-B2 protein (7-163AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CCNB2 Antibody (CSB-PA004808LA01HU)，的標記方式是Non-conjugated。對于CCNB2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004808LB01HU	CCNB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004808LC01HU	CCNB2 Antibody, FITC conjugated
Biotin	CSB-PA004808LD01HU	CCNB2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Essential for the control of the cell cycle at the G2/M (mitosis) transition.
基因功能參考文獻：
1. Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1), cyclin B2 (CCNB2) and c-myc (c-MYC) genes by binding to the conserved binding sites on their promoters or enhancers. PMID: 27183908
2. Data show that the cyclin B2 was overexpressed in bladder cancer tissue. PMID: 26706119
3. overexpression of CCNB2 protein is associated with clinical progression and poor prognosis in non-small cell lung cancer PMID: 26349989
4. Cyclin B1 and cyclin B2 are interchangeable for ability to promote G2 and M transition in HeLa cells. PMID: 24324638
5. there was no significance in the 5-year overall survival rates among the patients with squamous cell carcinoma between expressing lower and higher level of cyclin B2 mRNA PMID: 24375198
6. Suggest that cytoplasmic CCNB2 may function as an oncogene and could serve as a potential biomarker of unfavorable prognosis over short-term follow-up in breast cancer. PMID: 23282137
7. The relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher than that in normal controls and benign diseases group. Circulating CCNB2 mRNA level significantly correlated with cancer stage and metastasis status. PMID: 21161946
8. Data suggest that cyclin A2 helps initiate mitosis, in part through its effects on cyclin B1, and that cyclins B1 and B2 are particularly critical for the maintenance of the mitotic state. PMID: 20660152
9. Overexpression of B-type cyclins alters chromosomal segregation PMID: 11960377
10. p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function PMID: 12482752
11. cyclin B2 expression in colorectal adenocarcinoma is dependent on NF-Y PMID: 17289878
12. severe reduction by separate RNA interference of either cyclin B1 or cyclin B2 protein levels results in little or no alteration of the cell cycle and, more specifically, of mitosis progression PMID: 17533373
13. This gene may be used as a very reliable biomarker of lung adenocarcinoma. PMID: 17549666
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蛋白家族：

Cyclin family, Cyclin AB subfamily
數據庫鏈接：

HGNC: 1580

OMIM: 602755

KEGG: hsa:9133

STRING: 9606.ENSP00000288207

UniGene: Hs.194698

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