CCL16 Antibody

說明書

中文名稱：

CCL16兔多克隆抗體
貨號：

CSB-PA169235
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human Lymphoma tissue using CSB-PA169235(CCL16 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA169235(CCL16 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA169235(CCL16 Antibody) at dilution 1/760, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

O15467
基因名：

CCL16
別名：

C-C motif chemokine 16 antibody; CCL16 antibody; CCL16_HUMAN antibody; Chemokine (C-C motif) ligand 16 antibody; Chemokine CC-4 antibody; Chemokine LEC antibody; CKb12 antibody; HCC-4 antibody; HCC4 antibody; IL-10-inducible chemokine antibody; IL10 inducible chemokine antibody; IL10 inducible chemokine antibody; ILINCK antibody; LCC-1 antibody; LCC1 antibody; Liver CC chemokine 1 precursor antibody; Liver expressed chemokine antibody; Liver-expressed chemokine antibody; LMC antibody; Lymphocyte and monocyte chemoattractant antibody; Monotactin 1 antibody; Monotactin-1 antibody; MTN-1 antibody; Mtn1 antibody; NCC-4 antibody; NCC4 antibody; New CC chemokine 4 antibody; SCYA16 antibody; SCYL4 antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine subfamily A (Cys Cys) member 16 antibody; Small-inducible cytokine A16 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human CCL16
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
基因功能參考文獻：
1. Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID: 29768218
2. Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID: 27357396
3. High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID: 22857868
4. Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID: 21951809
5. Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID: 21288736
6. Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID: 14525962
7. An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID: 15034014
8. CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID: 15265943
9. CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID: 16226254
10. Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID: 19494526
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亞細胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
組織特異性：

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
數據庫鏈接：

HGNC: 10614

OMIM: 601394

KEGG: hsa:6360

STRING: 9606.ENSP00000293275

UniGene: Hs.10458

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