CCDC106 Antibody

說明書

中文名稱：

CCDC106兔多克隆抗體
貨號：

CSB-PA961263
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from Jurkat cells using Coiled-coil domain-containing protein 106 antibody and the same antibody preincubated with blocking peptide.
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CCDC106 Polyclonal antibody
Uniprot No.：

Q9BWC9
基因名：

CCDC106
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Peptide sequence around aa.2~6 (N-D-R-S-S) derived from Human Coiled-coil domain-containing protein 106.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
基因功能參考文獻：
1. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment. PMID: 28460455
2. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity. PMID: 20159018
亞細胞定位：

Nucleus. Note=Colocalizes with p53/TP53.
數(shù)據(jù)庫鏈接：

HGNC: 30181

OMIM: 613478

KEGG: hsa:29903

UniGene: Hs.82482

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