CBLIF Antibody

中文名稱：

CBLIF兔多克隆抗體
貨號：

CSB-PA009417LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA009417LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GIF Polyclonal antibody
Uniprot No.：

P27352
基因名：

GIF
別名：

CBLIF antibody; GIF antibody; IFMH antibody; Cobalamin binding intrinsic factor antibody; Gastric intrinsic factor antibody; Intrinsic factor antibody; IF antibody; INF antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cobalamin binding intrinsic factor protein (19-417AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，CBLIF Antibody (CSB-PA009417LA01HU)，的標記方式是Non-conjugated。對于CBLIF Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA009417LB01HU	CBLIF Antibody, HRP conjugated	ELISA
FITC	CSB-PA009417LC01HU	CBLIF Antibody, FITC conjugated
Biotin	CSB-PA009417LD01HU	CBLIF Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
基因功能參考文獻：
1. the present findings reveal that High-altitude polycythemia -induced gastric mucosal lesion inspires the protection responses by up-regulating APOA4 and APOC3, and down-regulating GIF. PMID: 26485402
2. Our genetic screening of 154 families of patients with inherited cobalamin malabsorption revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes: CUBN, AMN, and GIF. PMID: 22929189
3. Acute lymphoblastic leukemia and vitamin B12 deficiency secondary to a gastric intrinsic factor gene mutation PMID: 22556038
4. crystal structure of the complex between IF-Cbl and the cubilin IF-Cbl-binding-region (CUB(5-8)) determined at 3.3 A resolution PMID: 20237569
5. A polymorphism in the gastric intrinsic factor gene is associated with congenital intrinsic factor deficiency. PMID: 14695536
6. The parameters obtained for ligand and receptor binding in this study indicate that both full-length 50-kDA intrinsic factor and its 30-kDa and 20-kDa fragments may be involved in assimilation of cobalamin. PMID: 15736970
7. possible basis for the lack of interchangeability of human and rat IF receptors is presented PMID: 17954916
8. The Q5R mutation of the intrinsic factor gene predisposes to adult-onset pernicious anemia & other causes of low vitamin B12. In this mutation, intrinsic factor secretion is preserved but B12 absorption may be impaired. PMID: 18338170
9. a specific GIF mutation to be responsible for all Juvenile cobalamin deficiency cases of West-African origin so far was identified PMID: 19036097
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相關疾病：

Hereditary intrinsic factor deficiency (IFD)
亞細胞定位：

Secreted.
蛋白家族：

Eukaryotic cobalamin transport proteins family
組織特異性：

Gastric mucosa.
數(shù)據(jù)庫鏈接：

HGNC: 4268

OMIM: 261000

KEGG: hsa:2694

STRING: 9606.ENSP00000257248

UniGene: Hs.110014

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