CARMIL1 Antibody

中文名稱：

CARMIL1兔多克隆抗體
貨號：

CSB-PA713356LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of HepG2 cells with CSB-PA713356LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CARMIL1 Polyclonal antibody
Uniprot No.：

Q5VZK9
基因名：

CARMIL1
別名：

Acan 125 antibody; Capping protein; Arp2/3; and myosin I linker antibody; CARMIL homolog antibody; leucine rich repeat containing 16 antibody; Leucine-rich repeat-containing protein 16A antibody; LR16A_HUMAN antibody; Lrrc16 protein antibody; LRRC16A antibody; p116 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human F-actin-uncapping protein LRRC16A protein (1184-1295AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CARMIL1 Antibody (CSB-PA713356LA01HU)，的標記方式是Non-conjugated。對于CARMIL1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA713356LB01HU	CARMIL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA713356LC01HU	CARMIL1 Antibody, FITC conjugated
Biotin	CSB-PA713356LD01HU	CARMIL1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.
基因功能參考文獻：
1. A novel genetic variant in leucine-rich repeat-containing 16A (LRRC16A) has been associated with reduced ARDS risk. PMID: 27768389
2. LRRC16A plays a role in adult respiratory distress syndrome pathophysiology by interacting with, and being mediated through, platelets. PMID: 25254322
3. shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure PMID: 24318514
4. The results also suggest that the ability of CARMIL1 to inhibit CP in cells may be regulated. PMID: 23904264
5. Data suggest that CARMIL promotes uncapping by binding to a freely accessible site on Capping protein (CP) bound to a filament barbed end and inducing a change in the conformation of the actin-binding surface of CP. PMID: 22411988
6. The two CARMIL isoforms are both important for cell migration, but they have distinct functions.[CARMIL1, CARMIL2] PMID: 19846667
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium.
蛋白家族：

CARMIL family
組織特異性：

Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
數據庫鏈接：

HGNC: 21581

OMIM: 609593

KEGG: hsa:55604

STRING: 9606.ENSP00000331983

UniGene: Hs.649550

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