CAMTA1 Antibody, FITC conjugated

說明書

中文名稱：

CAMTA1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA897322LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CAMTA1 Polyclonal antibody
Uniprot No.：

Q9Y6Y1
基因名：

CAMTA1
別名：

CAMTA1 antibody; KIAA0833 antibody; MSTP023 antibody; Calmodulin-binding transcription activator 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calmodulin-binding transcription activator 1 protein (201-452AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional activator. May act as a tumor suppressor.
基因功能參考文獻：
1. This GWAS identified 2 loci at 10q23 (rs139550538; P = 1.87 x 10-9) and in the CAMTA1 gene at 1p36 (rs2412208, P = 3.53 x 10-8). genome-wide levels of significance that influence survival in patients with ALS. PMID: 27244217
2. TFE3 gene translocations are compossible with CAMTA1 gene rearrangements in Epithelioid hemangioendotheliomas. PMID: 26840265
3. Nuclear CAMTA1 expression is sensitive and highly specific for epithelioid haemangioendothelioma and can be applied to diagnostic immunohistochemistry in epithelioid tumours. PMID: 25879300
4. we demonstrate additional structural complexity in WWTR1-CAMTA1 fusion transcripts in epithelioid haemangioendothelioma PMID: 25817592
5. Our findings elucidate the mechanistic basis of the oncogenic properties of TAZ-CAMTA1 fusion PMID: 25961935
6. Nuclear expression of CAMTA1 can be used in the differential diagnosis of epithelioid hemangioendotheliomas. PMID: 26414223
7. Intragenic CAMTA1 deletions are associated with a spectrum of neurobehavioral phenotypes PMID: 24738973
8. Epithelioid hemangioendothelioma, it's potential mimickers, and other benign or malignant vascular tumors showed strong and diffuse CAMTA1 expression, nullifying it's potential use as an adjunct in the differential diagnosis. PMID: 25110239
9. Cell-cell communications between the stem cells and adjacent cardiomyocytes induce Ca(2+) signals that activate a myocardial gene program in the stem cells via a novel and early Ca(2+)-dependent intermediate, up-regulation of CAMTA1. PMID: 22715383
10. Report CAMTA1-WWTR1 gene fusion in thoracic epithelioid hemangioendothelioma but not epithelioid angiosarcoma. PMID: 25353289
11. The authors present evidence that loss-of-function of CAMTA1, a brain-specific calcium responsive transcription factor, is responsible for NPCA with or without ID. PMID: 22693284
12. Using reverse transcription-polymerase chain reaction (RT-PCR) and subsequent sequencing, we confirmed an identical WWTR1-CAMTA1 fusion transcript product from different nodules in each patient. PMID: 22429593
13. Results indicate that CAMTA1 genotype is associated with cognitive function in older adults with cardiovascular disease, because carriers of the T allele performed more poorly on tests of attention, executive function, and psychomotor speed. PMID: 21951953
14. CAMTA1 was identified as an miR-9/9* and miR- 17 target. CAMTA1 expression led to reduced neurosphere formation and growth of human glioblastomas in nude mice. Consistently, CAMTA1 and NPPA expression correlate with patient survival. PMID: 21857646
15. the presence of a WWTR1-CAMTA1 fusion in all EHE tested from bone, soft tissue, and visceral location PMID: 21584898
16. Findings define properties of CAMTA1 in growth suppression and neuronal differentiation that support its assignment as a 1p36 tumor suppressor gene in neuroblastoma. PMID: 21385898
17. FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate tumor suppressor genes of neuroblastoma PMID: 12964007
18. no evidence for somatic mutations in FLJ10737 in neuroblastoma PMID: 17222547
19. validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory. PMID: 17470457
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相關疾病：

Cerebellar ataxia, non-progressive, with mental retardation (CANPMR)
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

CAMTA family
組織特異性：

Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by ha
數據庫鏈接：

HGNC: 18806

OMIM: 611501

KEGG: hsa:23261

STRING: 9606.ENSP00000306522

UniGene: Hs.397705

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