CAMK1D Antibody

說明書

中文名稱：

CAMK1D兔多克隆抗體
貨號：

CSB-PA812863ESR2HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: CAMK1Dantibody at 2.9μg/ml
Lane 1: A549 whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 43, 41 kDa
Observed band size: 43 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CAMK1D Polyclonal antibody
Uniprot No.：

Q8IU85
基因名：

CAMK1D
別名：

A630059D12Rik antibody; Calcium/calmodulin dependent protein kinase ID antibody; Calcium/calmodulin dependent protein kinase type 1D antibody; Calcium/calmodulin-dependent protein kinase I-delta antibody; Calcium/calmodulin-dependent protein kinase type 1D antibody; CaM K1 antibody; CaM KI delta antibody; CaM kinase I delta antibody; CaM kinase ID antibody; CaM-KI delta antibody; CAMK 1D antibody; CAMK1D antibody; CaMKI delta antibody; CamKI like protein kinase antibody; CamKI-like protein kinase antibody; CaMKID antibody; CKLiK antibody; E030025C11Rik antibody; KCC1D_HUMAN antibody; OTTHUMP00000019119 antibody; OTTHUMP00000019120 antibody; OTTHUMP00000045030 antibody; RP11 462F15.1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calcium/calmodulin-dependent protein kinase type 1D protein (1-180AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
基因功能參考文獻：
1. There were no statistically significant differences in the distribution of CDC123/CAMK1D rs12779790 genotypes and alleles between women with gestational diabetes mellitus and healthy pregnant women. PMID: 28079868
2. identified the CAMK1D gene as a novel locus associated with blood pressure response to losartan PMID: 25410890
3. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). PMID: 22923468
4. A significant association of rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 was identified with type 2 diabetes in a Japanese population. PMID: 21909839
5. role of CKLiK in specific granulocyte effector functions such as phagocytosis, respiratory burst, migration, and adhesion PMID: 15840691
6. CAMK1D as a novel amplified oncogene linked to epithelial-mesenchymal transition in breast cancer, with elevated expression in invasive carcinomas compared to carcinoma in situ PMID: 19383354
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亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
組織特異性：

Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.
數(shù)據(jù)庫鏈接：

HGNC: 19341

OMIM: 607957

KEGG: hsa:57118

STRING: 9606.ENSP00000368124

UniGene: Hs.600547

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