CADM3 Antibody

說明書

中文名稱：

CADM3兔多克隆抗體
貨號：

CSB-PA004427GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8N126
基因名：

CADM3
別名：

BIgR antibody; Brain immunoglobulin receptor antibody; CADM 3 antibody; cadm3 antibody; CADM3_HUMAN antibody; Cell adhesion molecule 3 antibody; Dendritic cell nectin like protein 1 short isoform antibody; FLJ10698 antibody; IgSF4B antibody; Immunoglobulin superfamily member 4B antibody; Necl 1 antibody; Necl-1 antibody; NECL1 antibody; Nectin like 1 antibody; Nectin like protein 1 antibody; Nectin-like protein 1 antibody; Synaptic cell adhesion molecule 3 antibody; synCAM3 antibody; TSLC1 like 1 antibody; TSLC1 like protein 1 antibody; TSLC1-like protein 1 antibody; TSLL1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CADM3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
基因功能參考文獻：
1. CADM3 expression was increased in retinoblastoma tissues and cells. miR-140-5p inhibited CADM3 expression possibly by targeting the 3'-UTR. PMID: 29808799
2. Nectin-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (JAM)-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 and JAM-based cell-cell adhesion sites to form AJ- and TJ-like domains. PMID: 24112238
3. NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation. PMID: 20078932
4. Findings clearly reveal the structural basis for the cis-dimerization of nectins through the first Ig-like domains. PMID: 21325282
5. A link might exist between NECL1 and the extracellular matrix protein OPN in inhibiting the migration and invasion of U251 glioma ce PMID: 20598232
6. NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis. PMID: 18686605
7. Nec- 1 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
8. Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites PMID: 15741237
9. crystallographic analysis of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule PMID: 16467305
10. human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS PMID: 18420026
11. Expression of entry receptors nectin-1 and HVEM prevent entry of HSV-1 into human conjunctival epithelium. PMID: 18502984
12. suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation PMID: 19062177
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Cell junction.
蛋白家族：

Nectin family
組織特異性：

Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
數據庫鏈接：

HGNC: 17601

OMIM: 609743

KEGG: hsa:57863

UniGene: Hs.365689

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