CACNB2 Antibody, FITC conjugated

說明書

中文名稱：

CACNB2兔多克隆抗體, FITC偶聯
貨號：

CSB-PA804482LC01HU
規格：

￥880
其他：

產品詳情
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相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CACNB2 Polyclonal antibody
Uniprot No.：

Q08289
基因名：

CACNB2
別名：

AW060387 antibody; Ca(V) beta 2 antibody; CAB2 antibody; CACB2_HUMAN antibody; CACNB2 antibody; CACNLB2 antibody; Calcium channel voltage dependent subunit beta 2 antibody; Calcium channel voltage-dependent subunit beta 2 antibody; Calcium channel; voltage dependent; beta 2 subunit antibody; CAVB2 antibody; Cavbeta2 antibody; Cchb2 antibody; FLJ23743 antibody; Lambert Eaton Myasthenic syndrome antigen antibody; Lambert Eaton myasthenic syndrome antigen B antibody; Lambert-Eaton myasthenic syndrome antigen B antibody; MGC129334 antibody; MGC129335 antibody; Myasthenic (Lambert Eaton) syndrome antigen B antibody; Myasthenic syndrome antigen B antibody; MYSB antibody; Voltage dependent L type calcium channel subunit beta 2 antibody; Voltage-dependent L-type calcium channel subunit beta-2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Voltage-dependent L-type calcium channel subunit beta-2 protein (490-637AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
基因功能參考文獻：
1. Data show that an indispensable beta-subunit of the voltage-gated Ca(2+) channel Cav1.2 interaction with H-Ras is independently of Ca(2+) flux, suggesting the regulatory role of beta2 in transcriptional activation via the ERK/CREB pathway. PMID: 30150369
2. Our study shows that palmitoylation of CaVbeta2a is necessary for CaValpha1 trafficking to the plasma membrane. However, excessive number of palmitoylated CaVbeta2a leads to Ca(2+) overload and beta cell death. PMID: 28739256
3. Study showed that CACNB2 is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3-associated familial hypertrophic cardiomyopathy PMID: 28614222
4. Five serious mental disorders and three major cardiovascular diseases have recently been linked to the CACNB2 gene coding for the Cavbeta2 subunits PMID: 25966706
5. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood. PMID: 25313554
6. In the gene-based analysis, CACNB2 and CTCF showed the strongest evidence for association with schizophrenia in both the present samples and in those of the Psychiatric Genetics Consortium datasets. PMID: 24901509
7. Three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in Autism Spectrum Disorders (ASD)-affected families, are reported. PMID: 24752249
8. Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population. PMID: 24338417
9. Genetic variations in CYP17A1, CACNB2 and PLEKHA7 were related to blood pressure traits and/or hypertension in Chinese She population. PMID: 21963141
10. Genetic testing reveals disease-causing mutations in depolarizing sodium (SCN5A) or calcium (CaCNB2b) channels in 5 infants with rapid ventricular tachycardia, conduction abnormalities, and Brugada-like syndrome. PMID: 22090166
11. This study provided that cacnb2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
12. that genetic variation within CACNB2 may influence treatment-related outcomes in high-risk patients with hypertension. PMID: 21156931
13. CACNB2 is a possible novel early repolarization syndrome susceptibility gene. PMID: 20817017
14. We also identified a novel polymorphism (D601E) in CACNB2b that slowed inactivation of L-type calcium current (I(Ca,L)), significantly increased total charge. Slowed conduction was present. PMID: 20025708
15. Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits. PMID: 19106618
16. CACNB2 SNPs show genotypic association with Alzheimer disease. PMID: 19241460
17. The first Brugada syndrome mutation in CaCNB2b resulting in accelerated inactivation of L-type calcium channel current, is reported. PMID: 19358333
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相關疾病：

Brugada syndrome 4 (BRGDA4)
亞細胞定位：

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Calcium channel beta subunit family
組織特異性：

Expressed in all tissues.
數據庫鏈接：

HGNC: 1402

OMIM: 600003

KEGG: hsa:783

STRING: 9606.ENSP00000320025

UniGene: Hs.59093

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