CABIN1 Antibody

中文名稱：

CABIN1兔多克隆抗體
貨號：

CSB-PA23399A0Rb
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, Rat brain tissue
All lanes: CABIN1 antibody at 3.1µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 247, 238 kDa
Observed band size: 247 kDa

IHC image of CSB-PA23399A0Rb diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA23399A0Rb diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CABIN1 Polyclonal antibody
Uniprot No.：

Q9Y6J0
基因名：

CABIN1
別名：

A330070M20Rik antibody; Cabin 1 antibody; CABIN_HUMAN antibody; Cabin1 antibody; CAIN antibody; Calcineurin binding protein cabin 1 antibody; Calcineurin inhibitor antibody; Calcineurin-binding protein cabin-1 antibody; KIAA0330 antibody; PPP3IN antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Calcineurin-binding protein cabin-1 protein (1978-2123AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CABIN1 Antibody (CSB-PA23399A0Rb)，的標記方式是Non-conjugated。對于CABIN1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA23399B0Rb	CABIN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA23399C0Rb	CABIN1 Antibody, FITC conjugated
Biotin	CSB-PA23399D0Rb	CABIN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
基因功能參考文獻：
1. Results indicate an important role for LMP1 and Cabin1 in regulating apoptosis in nasopharyngeal carcinoma cells in response to genotoxic stress. PMID: 23939952
2. Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1. PMID: 23624525
3. Our findings demonstrate that hCABIN-1 plays a critical role in promoting apoptosis of fibroblast-like synoviocytes and in attenuating inflammation and cartilage and bone destruction in rheumatoid arthritis. PMID: 22275266
4. NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex PMID: 22401310
5. Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells. PMID: 21807893
6. CABIN1 may not confer increased susceptibility for schizophrenia in the Japanese population. PMID: 20075944
7. Crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution PMID: 12700764
8. there is a 13-amino acid region within CN that is essential for the interaction with NFAT and with two other CN-binding proteins, AKAP79 and Cabin-1 PMID: 15671033
9. Here, we report that Cabin1 has additional CN binding domain in its 701-900 amino acid residues. PMID: 17531200
10. Cabin1 inhibits p53 function on chromatin in the quiescent state; the presence of inactive p53 on some promoters might allow a prompt response upon DNA damage. PMID: 19668210
11. the association of CAIN with intracellular domains involved in mGluR/G protein coupling provides a mechanism by which Group I mGluR endocytosis and signaling are regulated PMID: 19717561
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亞細胞定位：

Nucleus.
組織特異性：

Widely expressed in different tissues.
數據庫鏈接：

HGNC: 24187

OMIM: 604251

KEGG: hsa:23523

STRING: 9606.ENSP00000263119

UniGene: Hs.517478

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