C9 Antibody
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中文名稱：C9兔多克隆抗體
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貨號：CSB-PA001095
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規格：￥1090
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圖片：
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Western Blot analysis of COLO205 cells using C9 Polyclonal Antibody -
Western Blot analysis of NIH-3T3 cells using C9 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：C9; Complement component C9
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human C9.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
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基因功能參考文獻：
- The data supports the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3) and angiogenic growth factors (VEGF) in retinal pigment epithelial cells. PMID: 30090015
- Serum-expressed apolipoprotein B-100 protein, C9 Complement, and gelsolin can be used for differential diagnosis of Barrertts esophagus and adenocarcinoma of esophagus. PMID: 26404905
- Data indicate that complement C9 binds to the ATPase domain of mortalin. PMID: 24719326
- Liver biopsy specimens from chronically hepatitis C virus-infected patients exhibited a lower level of C9 mRNA expression than liver biopsy specimens from unrelated disease or healthy control human liver RNA. PMID: 23487461
- the haploinsufficiency of C9, a terminal complement complex component, engenders reduced intraocular secretion of VEGF and decreased risk for CNV development. PMID: 22190594
- C9 and fucosylated form could serve as a useful marker for SQLC. PMID: 21840429
- It was concluded that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. PMID: 21380615
- Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. PMID: 21507937
- These results suggested that the lack of membrane attack complex because of an Arg95Stop mutation of the complement component 9 gene predisposed patients to pathognomonic glomerulonephritis. PMID: 21057849
- provided evidence for the recognition of membrane-bound C9 on complement-lysed ghosts by an antibody specific for the helix-turn-helix fold. PMID: 20153530
- Data show that mortalin supports cancer cell resistance to complement-dependent cytotoxicity and suggest consideration of mortalin as a novel target for cancer adjuvant immunotherapy. PMID: 19739077
- The human complement C9 gene: structural analysis of the 5' gene region and genetic polymorphism studies. PMID: 11881818
- C9 binding is dependent on the N-terminal modules (thrombospondin type 1 and low-density lipoprotein receptor class A) of C8 alpha together with the C8 alpha membrane attack complex/perforin domain. PMID: 12463754
- Founder effect was demonstrated for the R95X mutation of the C9 gene in Japanese PMID: 12596049
- results indicate that the principal binding site for C9 lies within the MACPF domain of C8alpha PMID: 16618117
- analysis of the CD59-C9 binding interaction PMID: 16844690
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相關疾病：Complement component 9 deficiency (C9D); Macular degeneration, age-related, 15 (ARMD15)
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亞細胞定位：Secreted. Target cell membrane; Multi-pass membrane protein.
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蛋白家族：Complement C6/C7/C8/C9 family
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組織特異性：Plasma (at protein level).
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數據庫鏈接：
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