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中文名稱：BZLF2兔多克隆抗體, Biotin偶聯(lián)
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貨號(hào)：CSB-PA365876LD01EFA
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Epstein-Barr virus BZLF2 Polyclonal antibody
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Uniprot No.：
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基因名：BZLF2
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別名：BZLF2Glycoprotein 42 antibody; gp42) [Cleaved into: Soluble gp42] antibody
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宿主：Rabbit
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反應(yīng)種屬：Epstein-Barr virus
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免疫原：Recombinant Epstein-Barr virus Glycoprotein 42 protein (34-223AA)
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免疫原種屬：Epstein-Barr virus
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells. Additionally, hampers T-cell recognition via HLA class II molecules through steric hindrance of T-cell receptor-class II-peptide interaction.; Soluble gp42 inhibits HLA class II-restricted antigen presentation to T-cells through binding to immature and mature HLA class II complexes.
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基因功能參考文獻(xiàn)：
- gp42 mutants bound to gH/gL and HLA class II, but not wild-type gp42 or cleavage mutant of gp42; using purified gp42, gH/gL, and HLA, found these proteins associate 1:1:1 suggesting gp42 dimerization or multimerization does not occur or is transient PMID: 21550622
- reveal distinct functional requirements for gH/gL and gp42 complexes in Epstein-Barr virus-mediated membrane fusion PMID: 16973550
- This screening demonstrates that LF2 specifically interacts with the central inhibitory association domain of IRF7, and this interaction leads to inhibition of the dimerization of IRF7, which suppresses IFN-alpha production and IFN-mediated immunity. PMID: 18987133
- Enhanced secretion of gp42 promoted fusion with B lymphocytes, and mutation of the site of gp42 cleavage inhibited membrane fusion activity. PMID: 19369343
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亞細(xì)胞定位：Virion membrane. Host membrane; Single-pass membrane protein.
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蛋白家族：Epstein barr virus gp42 family
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數(shù)據(jù)庫(kù)鏈接：
KEGG: vg:3783745
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