BNIP1 Antibody
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中文名稱：BNIP1兔多克隆抗體
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貨號：CSB-PA623663ESR2HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA623663ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA623663ESR2HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) BNIP1 Polyclonal antibody
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Uniprot No.：
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基因名：BNIP1
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別名：BCL2 adenovirus E1B 19kD interacting protein 1 antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 1 antibody; BNIP1 antibody; MGC41600 antibody; Nip1 antibody; OTTHUMP00000161077 antibody; OTTHUMP00000161078 antibody; OTTHUMP00000161079 antibody; OTTHUMP00000223580 antibody; sec20 antibody; SEC20_HUMAN antibody; SEC20L antibody; Transformation-related gene 8 protein antibody; TRG-8 antibody; TRG8 antibody; Vesicle transport protein SEC20 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Vesicle transport protein SEC20 protein (1-200AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Plays also a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
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基因功能參考文獻：
- The mitochondrial targeting domain (MTD) of Noxa has necrosis-inducing activity when conjugated with cell-penetrating peptide (CPP). In this study, we report another MTD-like motif, B1MLM, found in BNIP1, a pro-apoptotic BH3-only protein found in the endoplasmic reticulum membrane. The B1MLM peptide, conjugated with CPP, induced necrosis in a way similar to that of R8:MTD. PMID: 29222049
- BNip1 functions as a downstream modulator of RNF186 to direct endoplasmic reticulum stress-associated apoptotic signaling. PMID: 23896122
- three members of the BNIP family, BNIP1, BNIP3 and BNIP3L, are expressed in the developing brain with distinct brain region specificity PMID: 22639046
- ER-specific BNIP1 plays an important role in mitochondrial dynamics by modulating the mitochondrial fission protein Drp1 PMID: 22020994
- Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo. PMID: 21931693
- soluble N-ethylmaleimide-sensitive factor attachment protein may suppress apoptosis by competing with antiapoptotic proteins for the BH3 domain of BNIP1 PMID: 15272311
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亞細胞定位：Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein.
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蛋白家族：SEC20 family
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組織特異性：Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
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數(shù)據(jù)庫鏈接：
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