BLOC1S1 Antibody

中文名稱：

BLOC1S1兔多克隆抗體
貨號：

CSB-PA00495A0Rb
規格：

￥440
圖片：
Western blot
All lanes: BLOC1S1 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 18, 15 kDa
Observed band size: 75 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA00495A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA00495A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA00495A0Rb at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) BLOC1S1 Polyclonal antibody
Uniprot No.：

P78537
基因名：

BLOC1S1
別名：

BLOC1S1 antibody; BLOS1 antibody; GCN5L1 antibody; RT14Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody; BLOC-1 subunit 1 antibody; GCN5-like protein 1 antibody; Protein RT14 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1 protein (1-153AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，BLOC1S1 Antibody (CSB-PA00495A0Rb)，的標記方式是Non-conjugated。對于BLOC1S1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA00495B0Rb	BLOC1S1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA00495C0Rb	BLOC1S1 Antibody, FITC conjugated
Biotin	CSB-PA00495D0Rb	BLOC1S1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
基因功能參考文獻：
1. The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton. PMID: 23676666
2. BLOS1 interacts with KXD1. PMID: 22554196
3. GCN5L1 interacts with and promotes acetylation of SIRT3 respiratory chain targets and reverses global SIRT3 effects on mitochondrial protein acetylation, respiration and bioenergetics PMID: 22309213
4. Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility. PMID: 22423091
5. GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria. PMID: 22309213
6. Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis. PMID: 17618940
7. Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts. PMID: 19246570
8. Biogenesis of Lysosome-related Organelles complex-1 (BLOC-1) subunit 1 (BLOS1). PMID: 15102850
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亞細胞定位：

Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.
蛋白家族：

BLOC1S1 family
數據庫鏈接：

HGNC: 4200

OMIM: 601444

KEGG: hsa:2647

STRING: 9606.ENSP00000447537

UniGene: Hs.600940

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