BEX1 Antibody

中文名稱：

BEX1兔多克隆抗體
貨號：

CSB-PA862062LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA862062LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) BEX1 Polyclonal antibody
Uniprot No.：

Q9HBH7
基因名：

BEX1
別名：

BEX1Protein BEX1 antibody; Brain-expressed X-linked protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein BEX1 protein (1-125AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，BEX1 Antibody (CSB-PA862062LA01HU)，的標記方式是Non-conjugated。對于BEX1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA862062LB01HU	BEX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA862062LC01HU	BEX1 Antibody, FITC conjugated
Biotin	CSB-PA862062LD01HU	BEX1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
基因功能參考文獻：
1. BEX1 was downregulated in esophageal squamous cell cancer (ESCC) tissues compared to adjacent normal tissues, and low BEX1 expression was significantly associated with larger tumor volume, advanced clinical, and poor survival in patients with ESCC. PMID: 30132532
2. BEX1 functions as an mRNA-dependent effector that augments pathology-promoting gene expression during heart failure. PMID: 29192139
3. loss of BEX1 expression in FLT3-ITD driven AML potentiates oncogenic signaling and leads to decreased overall survival PMID: 26046670
4. Our results revealed an interaction between BEX1 and BCL-2 and a novel mechanism of imatinib resistance mediated by the BEX1/BCL-2 pathway. PMID: 24626299
5. Bex family members play important roles in the formation of protein network hubs. PMID: 25612294
6. Epigenetic inactivation of BEX1 supports its role as a candidate tumour suppressor gene in intracranial ependymoma PMID: 24333734
7. Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence. PMID: 23362108
8. This new human gene is mapped to the X chromosome and has an expression pattern of a spermatogenesis-related gene. PMID: 11989783
9. Two novel brain expressed genes, BEX1 and BEX2 are identified; they are silenced in all glioma specimens and exhibit extensive promoter hypermethylation. PMID: 16818640
10. expression of hBex1 in leukemic cells is a novel mechanism by which chemoresistance is achieved and suggests that hBex1 is a potential molecular target for the development of novel leukemia treatments PMID: 19028701
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

BEX family
組織特異性：

Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
數據庫鏈接：

HGNC: 1036

OMIM: 300690

KEGG: hsa:55859

STRING: 9606.ENSP00000361813

UniGene: Hs.334370

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