BCDIN3D Antibody, HRP conjugated
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中文名稱：BCDIN3D兔多克隆抗體, HRP偶聯
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貨號：CSB-PA767206LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) BCDIN3D Polyclonal antibody
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Uniprot No.：
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基因名：BCDIN3D
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別名：BCDIN3 domain containing antibody; BCDIN3 domain-containing protein antibody; BCDIN3D antibody; BN3D2_HUMAN antibody; Probable methyltransferase BCDIN3D antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Pre-miRNA 5'-monophosphate methyltransferase protein (1-292AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
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基因功能參考文獻：
- BCDIN3D might serve as an important prognostic factor for triple-negative breast cancer PMID: 27259993
- BCDIN3D acts as a cytoplasmic tRNAHis-specific 5-methylphosphate capping enzyme. PMID: 28119416
- Human BCDIN3D monomethylates the 5'-monophosphate of cytoplasmic tRNAHis in vitro. In BCDN3D-knockout cells, established byCRISPR/Cas9 editing, the methyl moiety at the 5'-monophosphate of cytoplasmic tRNAHis is lost, and the exogenous expression of BCDIN3D in the knockout cells restores the modification in cytoplasmic tRNAHis. PMID: 28119416
- BCDIN3D depletion leads to lower pre-miR-145 and concomitantly increased mature miR-145 levels in breast cancer cells, which suppresses their tumorigenic phenotypes. PMID: 23063121
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亞細胞定位：Cytoplasm.
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蛋白家族：Methyltransferase superfamily
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數據庫鏈接：
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