BCAS2 Antibody

說明書

中文名稱：

BCAS2兔多克隆抗體
貨號：

CSB-PA002597ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002597ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002597ESR2HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) BCAS2 Polyclonal antibody
Uniprot No.：

O75934
基因名：

BCAS2
別名：

bcas2 antibody; Breast carcinoma amplified sequence 2 antibody; Breast carcinoma-amplified sequence 2 antibody; DAM 1 antibody; DAM-1 antibody; DAM1 antibody; DNA amplified in mammary carcinoma 1 protein antibody; MGC7712 antibody; Pre mRNA splicing factor SPF27 antibody; Pre-mRNA-splicing factor spf27 antibody; Snt309 antibody; SPF27 antibody; SPF27_HUMAN antibody; Spliceosome associated protein amplified in breast cancer antibody; Spliceosome associated protein SPF 27 antibody; Spliceosome-associated protein SPF 27 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Pre-mRNA-splicing factor SPF27 protein (1-225AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
基因功能參考文獻：
1. Study showed that CDK4 and BCAS2 may be target genes of miR-486 and levels of CDK4 and BCAS2 were both significantly higher in the esophageal cancer tissues and cell lines than levels in the normal tissues and cells. PMID: 29115564
2. Chromosomal breakpoints involved the BCAS2 gene in 1q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
3. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. PMID: 26319152
4. These results demonstrate that Aurora B inhibits both direct interaction with the microtubule and oligomerization of the Dam1 complex to drive error correction during mitosis. PMID: 26560693
5. BCAS2 is a novel androgen receptor-interacting protein. PMID: 25461807
6. ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin PMID: 24667650
7. The BCAS2 gene was amplified in two of 60 primary breast cancer tissues, but not in other cancer cells, providing the first evidence of amplification within this region and indicating that BCAS2 gene codes for a nuclear protein. PMID: 12169396
8. This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function. PMID: 15694360
9. BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence of DNA damage. In the presence of DNA damage, BCAS2 prominently reduces p53 protein. PMID: 19903847
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亞細胞定位：

Nucleus. Nucleus, nucleolus.
蛋白家族：

SPF27 family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 975

OMIM: 605783

KEGG: hsa:10286

STRING: 9606.ENSP00000358554

UniGene: Hs.22960

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