AZIN1 Antibody

中文名稱：

AZIN1兔多克隆抗體
貨號：

CSB-PA002484LA01HU
規格：

￥440
圖片：
Western blot
All lanes: AZIN1 antibody at 4µg/ml
Lane 1: Mouse liver tissue
Lane 2: PC-3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA002484LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002484LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AZIN1 Polyclonal antibody
Uniprot No.：

O14977
基因名：

AZIN1
別名：

Antizyme inhibitor 1 antibody; AZI antibody; Azin1 antibody; AZIN1_HUMAN antibody; OAZI antibody; OAZIN antibody; ODC1L antibody; Ornithine decarboxylase antizyme inhibitor antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Antizyme inhibitor 1 protein (101-400AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AZIN1 Antibody (CSB-PA002484LA01HU)，的標記方式是Non-conjugated。對于AZIN1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA002484LB01HU	AZIN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002484LC01HU	AZIN1 Antibody, FITC conjugated
Biotin	CSB-PA002484LD01HU	AZIN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
基因功能參考文獻：
1. Using high-resolution (1)H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure. PMID: 30063205
2. e in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer. PMID: 28849733
3. AzI1 fulfils an essential regulatory function in polyamine homeostasis and cell proliferation. PMID: 25813938
4. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). PMID: 26305948
5. This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. PMID: 15670771
6. edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 PMID: 23291631
7. minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells. PMID: 21837750
8. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. PMID: 21931692
9. SNP rs2679757 in the AZIN1 gene is associated with the risk of HBV-related liver cirrhosis in Chinese patients. PMID: 21586232
10. Decreased ornithine decarboxylase is associated with prostate cancer. PMID: 20215859
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亞細胞定位：

Nucleus.
蛋白家族：

Orn/Lys/Arg decarboxylase class-II family, ODC antizyme inhibitor subfamily
組織特異性：

Expressed in liver.
數據庫鏈接：

HGNC: 16432

OMIM: 607909

KEGG: hsa:51582

STRING: 9606.ENSP00000321507

UniGene: Hs.459106

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