ATXN1L Antibody

中文名稱：

ATXN1L兔多克隆抗體
貨號：

CSB-PA002440LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA002440LA01HU at dilution of 1:100
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ATXN1L Polyclonal antibody
Uniprot No.：

P0C7T5
基因名：

ATXN1L
別名：

ATXN1L antibody; BOAT antibody; BOAT1Ataxin-1-like antibody; Brother of ataxin-1 antibody; Brother of ATXN1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ataxin-1-like protein (183-463AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ATXN1L Antibody (CSB-PA002440LA01HU)，的標記方式是Non-conjugated。對于ATXN1L Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA002440LB01HU	ATXN1L Antibody, HRP conjugated	ELISA
FITC	CSB-PA002440LC01HU	ATXN1L Antibody, FITC conjugated
Biotin	CSB-PA002440LD01HU	ATXN1L Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
基因功能參考文獻：
1. The ATXN1L-CIC-ETS transcription factor axis as a mediator of resistance to MAPKi. PMID: 28178529
2. Both ATXN1 and BOAT1 bind to the promoter region of Hey1 and inhibit the transcriptional output of Notch through direct interactions with CBF1, a transcription factor that is crucial for the Notch pathway. PMID: 21475249
3. Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals PMID: 16121196
亞細胞定位：

Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
蛋白家族：

ATXN1 family
組織特異性：

Expressed in cerebellum and cerebral cortex.
數據庫鏈接：

HGNC: 33279

OMIM: 614301

KEGG: hsa:342371

STRING: 9606.ENSP00000415822

UniGene: Hs.743239

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