ATP6V1H Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q9UI12
基因名：

ATP6V1H
別名：

Atp6v1h antibody; ATPase; H+ transporting; lysosomal 50/57kDa; V1 subunit H antibody; CGI 11 antibody; CGI11 antibody; EC 3.6.3.14 antibody; MSTP042 antibody; NBP1 antibody; Nef binding protein 1 antibody; Nef-binding protein 1 antibody; Protein VMA13 homolog antibody; SFD antibody; SFDalpha antibody; SFDbeta antibody; V ATPase subunit H antibody; V-ATPase 50/57 kDa subunits antibody; V-ATPase subunit H antibody; V-type proton ATPase subunit H antibody; Vacuolar ATP synthase subunit H antibody; Vacuolar proton pump subunit H antibody; Vacuolar proton pump subunit SFD antibody; VATH_HUMAN antibody; VMA13 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human V-ATPase H.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.
基因功能參考文獻(xiàn)：
1. These data provide evidence that partial loss of ATP6V1H function results in osteoporosis/osteopenia. PMID: 27924156
2. These studies have uncovered a new, ATP6V1H-mediated pathway that regulates bone formation, and defines a new mechanism of disease that leads to bone loss. We propose that MMP9/MMP13 could be therapeutic targets for patients with this rare genetic disease. PMID: 28158191
3. ATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity. PMID: 21871445
4. Our study shows that multiple mechanisms of pump dysfunction result from B1 subunit mutations with a common outcome being defective assembly PMID: 18368028
蛋白家族：

V-ATPase H subunit family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 18303

OMIM: 608861

KEGG: hsa:51606

STRING: 9606.ENSP00000352522

UniGene: Hs.491737

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