ASPRV1 Antibody

說明書

產品詳情

Uniprot No.：

Q53RT3
基因名：

ASPRV1
別名：

ASPRV1; SASP; Retroviral-like aspartic protease 1; Skin-specific retroviral-like aspartic protease; SASPase; Skin aspartic protease; TPA-inducible aspartic proteinase-like protein; TAPS
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human ASPRV1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.
基因功能參考文獻：
1. results failed to find an association between ASPRV1 gene mutations and atopic eczema or clinically dry skin in the European populations studied PMID: 22318384
2. SASPase activity is indispensable for processing profilaggrin and maintaining the texture and hydration of the stratum corneum. PMID: 21542132
3. Identification and characterization of a new member of the aspartic proteases family, a unique epidermal retroviral-like protease, Skin ASpartic Protease. PMID: 16098038
4. Taps expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin. PMID: 16565508
亞細胞定位：

Membrane; Single-pass membrane protein.
組織特異性：

Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent f
數據庫鏈接：

HGNC: 26321

OMIM: 611765

KEGG: hsa:151516

STRING: 9606.ENSP00000315383

UniGene: Hs.516253

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