ASB9 Antibody

中文名稱：

ASB9兔多克隆抗體
貨號：

CSB-PA853405LA01HU
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ASB9 Polyclonal antibody
Uniprot No.：

Q96DX5
基因名：

ASB9
別名：

ASB9 antibody; Ankyrin repeat and SOCS box protein 9 antibody; ASB-9 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Ankyrin repeat and SOCS box protein 9 protein (1-294AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，ASB9 Antibody (CSB-PA853405LA01HU)，的標(biāo)記方式是Non-conjugated。對于ASB9 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA853405LB01HU	ASB9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA853405LC01HU	ASB9 Antibody, FITC conjugated
Biotin	CSB-PA853405LD01HU	ASB9 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
基因功能參考文獻(xiàn)：
1. Model of ASB9 in complex with its substrate, creatine kinase, reveals a mechanism for dynamic ubiquitin transfer. PMID: 27396830
2. Molecular docking yielded a structural model consistent with all of the data that suggested the N-terminal residues of ASB9(1-252) may lie in one CK active site. This model was corroborated by enzymatic activity assays and mutational analysis. PMID: 25654263
3. ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
4. His103 and Phe107 in hASB9-2 are essential for binding to CKB. PMID: 22418839
5. The results of the present study suggest that ASB9 is a useful prognostic marker for colorectal cancer PMID: 20878058
6. ASB9 interacts with the creatine kinase system and negatively regulates cell growth. PMID: 20302626
7. The splice variant of hASB9, hASB9-2 protein, was cloned, overexpressed, and crystallized and the data showed that the cubic hASB9-2 crystal belongs to space group P4(3)32 with unit-cell parameters. PMID: 18680464
8. The purified ASB9-2 protein, the splice variant of ASB9 with only one ankyrin repeat domain, was crystallized and diffracted to 2.2A resolution. PMID: 19275750
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亞細(xì)胞定位：

Mitochondrion.
蛋白家族：

Ankyrin SOCS box (ASB) family
組織特異性：

Predominantly expressed in testis, kidney, and liver.
數(shù)據(jù)庫鏈接：

HGNC: 17184

OMIM: 300890

KEGG: hsa:140462

STRING: 9606.ENSP00000369855

UniGene: Hs.19404

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