ARMCX3 Antibody

說明書

中文名稱：

ARMCX3兔多克隆抗體
貨號：

CSB-PA707391
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA707391(ARMCX3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A172 cells, K562 cells, mouse pancreas tissue, Primary antibody: CSB-PA707391(ARMCX3 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
其他：

產品詳情

Uniprot No.：

Q9UH62
基因名：

ARMCX3
別名：

ARMCX3 antibody; ALEX3 antibody; BM-017 antibody; UNQ2517/PRO6007Armadillo repeat-containing X-linked protein 3 antibody; ARM protein lost in epithelial cancers on chromosome X 3 antibody; Protein ALEX3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human ARMCX3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.
基因功能參考文獻：
1. reduction of Alex3 correlates with the development of non-small cell lung cancer and predicts adverse clinical outcome of non-small cell lung cancer patients. The effect of Alex3 on inhibiting invasion and migration may attribute to upregulation of E-cadherin expression through AKT-Slug pathway inactivation. PMID: 28705116
2. The Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation. PMID: 23844091
亞細胞定位：

Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus.
蛋白家族：

Eutherian X-chromosome-specific Armcx family
數據庫鏈接：

HGNC: 24065

OMIM: 300364

KEGG: hsa:51566

STRING: 9606.ENSP00000340672

UniGene: Hs.592225

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