ARMC8 Antibody

說明書

產品詳情

Uniprot No.：

Q8IUR7
基因名：

ARMC8
別名：

Armadillo repeat containing protein 8 antibody; Armadillo repeat-containing protein 8 antibody; ARMC8 antibody; ARMC8_HUMAN antibody; HSPC056 antibody; MGC10058 antibody; MGC4880 antibody; S863 2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human ARMC8
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
基因功能參考文獻：
1. Knockdown of ARMC8 significantly inhibited osteosarcoma cell proliferation in vitro and markedly inhibited xenograft tumor growth in vivo. ARMC8 silencing also suppressed the epithelial-mesenchymal transition (EMT) phenotype, as well as inhibited the migration and invasion of osteosarcoma cells. PMID: 27712595
2. results indicate that Armc8 may be a potential cancer marker in hepatocellular carcinoma PMID: 26944057
3. invasiveness and migration capacity of HT29 cells transfected with ARMc8 were significantly greater than those of control cells (p < 0.001), while ARMc8 siRNA treatment significantly reduced cell invasion and migration in LoVo cells PMID: 26081621
4. ARMc8 may enhance the invasion and metastasis of ovarian cancer cells PMID: 26232863
5. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. PMID: 25119601
6. Data suggest that armadillo repeat containing protein 8 (ARMC8) might serve as a therapeutic target in non-small cell lung cancer (NSCLC). PMID: 24894675
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亞細胞定位：

Nucleus. Cytoplasm.
數據庫鏈接：

HGNC: 24999

KEGG: hsa:25852

STRING: 9606.ENSP00000420333

UniGene: Hs.744868

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