ARIH2 Antibody
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中文名稱：ARIH2兔多克隆抗體
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貨號：CSB-PA002069GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ARIH2
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別名：HT005 antibody; all trans retinoic acid inducible RING finger antibody; Ari 2 antibody; Ari-2 antibody; ARI2 antibody; ARI2_HUMAN antibody; Ariadne 2 antibody; Ariadne 2 protein homolog antibody; ariadne homolog 2 (Drosophila) antibody; ariadne homolog 2 antibody; Ariadne RBR E3 ubiquitin protein ligase 2 antibody; ARIH 2 antibody; Arih2 antibody; E3 ubiquitin protein ligase ARIH2 antibody; E3 ubiquitin-protein ligase ARIH2 antibody; protein ariadne 2 homolog antibody; Protein ariadne-2 homolog antibody; Triad 1 antibody; TRIAD1 antibody; Triad1 protein antibody; UIP48 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ARIH2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis.
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基因功能參考文獻：
- these findings reveal a novel mechanism of ubiquitination-dependent negative regulation of the NLRP3 inflammasome by ARIH2 and highlight ARIH2 as a potential therapeutic target for inflammatory diseases PMID: 29021376
- We show that ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation PMID: 24486325
- TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. PMID: 24076655
- study demonstrated that TRIAD1 is a ubiquitination target for proteasome-dependent degradation by MDM2; results suggest TRIAD1 degradation by MDM2 suppresses TRIAD1-mediated cell growth; data suggested a novel negative regulatory mechanism of TRIAD1 via MDM2 E3 ligase ubiquitination PMID: 22940738
- TRIAD1 as a novel modulator of the p53-MDM2 axis that induces p53 activation by inhibiting its regulation by MDM2. PMID: 22819825
- In sharp contrast to SIAH1/SIAH2 and UBCH8, TRIAD1 binding to PML-RARalpha has no effect on its turnover. PMID: 22037423
- HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1 PMID: 21454682
- proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells PMID: 16118314
- The fine-tuning of Gfi1 protein levels regulated by Triad1 defines an unexpected role for this protein in hematopoiesis. PMID: 17646546
- Triad1 has dual ubiquitin ligase activity; both its RING domains are crucial for inhibiting myeloid proliferation. The N-terminal RING finger (RING1) of Triad1 binds UbcH7; the C-terminal RING finger (RING2) binds Ubc13. PMID: 19340006
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：RBR family, Ariadne subfamily
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組織特異性：Widely expressed with higher expression in granulocytes.
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數據庫鏈接：
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