ARHGAP11B Antibody

說(shuō)明書(shū)

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) ARHGAP11B Polyclonal antibody
Uniprot No.：

Q3KRB8
基因名：

ARHGAP11B
別名：

ARHGAP11B antibody; FAM7B1 antibody; Rho GTPase-activating protein 11B antibody; Protein FAM7B1 antibody; Rho-type GTPase-activating protein 11B antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Rho GTPase-activating protein 11B protein (99-231AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，ARHGAP11B Antibody (CSB-PA664668LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ARHGAP11B Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱(chēng)	應(yīng)用
HRP	CSB-PA664668LB01HU	ARHGAP11B Antibody, HRP conjugated	ELISA
FITC	CSB-PA664668LC01HU	ARHGAP11B Antibody, FITC conjugated
Biotin	CSB-PA664668LD01HU	ARHGAP11B Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
基因功能參考文獻(xiàn)：
1. The data also demonstrate that a single C-->G base substitution underlies the ARHGAP11B-mediated basal progenitor amplification implicated in neocortex expansion. PMID: 27957544
2. ARHGAP11B may have contributed to evolutionary expansion of human neocortex. PMID: 25721503
亞細(xì)胞定位：

Mitochondrion matrix.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 15782

OMIM: 616310

KEGG: hsa:89839

STRING: 9606.ENSP00000392760

UniGene: Hs.659621

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