ARFGAP1 Antibody

說明書

中文名稱：

ARFGAP1兔多克隆抗體
貨號：

CSB-PA843284ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: ADP-ribosylation factor GTPase-activating protein 1 antibody at 8μg/ml
Lane 1: PC-3 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45, 46, 32, 40 kDa
Observed band size: 45 kDa

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA843284ESR1HU at dilution of 1: 100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ARFGAP1 Polyclonal antibody
Uniprot No.：

Q8N6T3
基因名：

ARFGAP1
別名：

ADP ribosylation factor 1 GTPase activating protein antibody; ADP ribosylation factor GTPase activating protein 1 antibody; ADP-ribosylation factor 1 GTPase-activating protein antibody; ADP-ribosylation factor GTPase-activating protein 1 antibody; ARF GAP 1 antibody; ARF1 directed GTPase activating protein antibody; ARF1 GAP antibody; ARF1-directed GTPase-activating protein antibody; ARF1GAP antibody; ARFG1_HUMAN antibody; Arfgap1 antibody; GAP protein antibody; HRIHFB2281 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human ADP-ribosylation factor GTPase-activating protein 1 protein (1-220AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.
基因功能參考文獻：
1. ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes. PMID: 25397679
2. ARFGAP1 is a host factor for Hepatitis C Virus RNA replication, and is hijacked by HCV NS5A to remove COPI cargo Sac1 from the site of HCV replication to maintain high levels of PI4P. PMID: 24623438
3. ArfGAP1 is identified as the first GTPase activating protein (GAP) for leucine-rich repeat kinase 2 (LRRK2). PMID: 22423108
4. role of ARFGAP1 in AP-2-regulated endocytosis has mechanistic parallels with its roles in COPI transport, as both its GAP activity and coat function contribute to promoting AP-2 transport PMID: 21499258
5. The small GTPases of the Ras superfamily mediate numerous biological processes through their ability to cycle between an inactive GDP-bound and an active GTP-bound form. PMID: 15246431
6. ArfGAP1 interacts with the Golgi through multiple hydrophobic motifs and that alternative modes of interaction may exist in tissue-specific ArfGAP1 isoforms. PMID: 16316994
7. SMAP2 functions in the retrograde, early endosome-to-trans golig network pathway in a clathrin- and AP-1-dependent manner. PMID: 16571680
8. coatomer is an allosteric regulator of Arf GAP1 PMID: 18541532
9. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking PMID: 19015319
10. catalytic amounts of Arf1GAP1 significantly reduce the yield of purified COPI vesicles PMID: 19055691
11. ArfGAP1, ArfGAP2, and ArfGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport. PMID: 19299515
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亞細胞定位：

Cytoplasm. Golgi apparatus.
數據庫鏈接：

HGNC: 15852

OMIM: 608377

KEGG: hsa:55738

STRING: 9606.ENSP00000314615

UniGene: Hs.25584

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