ARAP1 Antibody

說明書

中文名稱：

ARAP1兔多克隆抗體
貨號：

CSB-PA565827
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA565827(ARAP1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q96P48
基因名：

ARAP1
別名：

2410002L19Rik antibody; ANK repeat and PH domain-containing protein 1 antibody; ARAP 1 antibody; Arap1 antibody; ARAP1_HUMAN antibody; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1 antibody; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1 antibody; Arf-GAP with Rho-GAP domain antibody; CENT D2 antibody; Centaurin delta 2 antibody; Centaurin delta2 antibody; Centaurin-delta-2 antibody; CENTD 2 antibody; CENTD2 antibody; Cnt d2 antibody; Cnt-d2 antibody; Cntd2 antibody; KIAA0782 antibody; MGC176140 antibody; mKIAA0782 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human ARAP1
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
基因功能參考文獻(xiàn)：
1. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression. PMID: 28132686
2. Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population. PMID: 25749274
3. The proinsulin-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets. PMID: 24439111
4. a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway. PMID: 22573888
5. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. PMID: 22357923
6. Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release. PMID: 21267535
7. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking PMID: 21275903
8. PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. PMID: 20554524
9. ARAP1 acts primarily on Arf6 in vivo. PMID: 18003747
10. ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death. PMID: 18165900
11. ARAP1 controls the late steps of the endocytic trafficking of the EGF-R PMID: 18764928
12. ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation PMID: 18939958
13. Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity. PMID: 19666464
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亞細(xì)胞定位：

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
組織特異性：

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
數(shù)據(jù)庫鏈接：

HGNC: 16925

OMIM: 606646

KEGG: hsa:116985

STRING: 9606.ENSP00000377233

UniGene: Hs.503165

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