APOO Antibody, FITC conjugated

說明書

中文名稱：

APOO兔多克隆抗體, FITC偶聯
貨號：

CSB-PA001948LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) APOO Polyclonal antibody
Uniprot No.：

Q9BUR5
基因名：

APOO
別名：

APOO; FAM121B; MIC23; MIC26; My025; UNQ1866/PRO4302; MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121B
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human MICOS complex subunit MIC26 protein (26-198AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.
基因功能參考文獻：
1. The human apolipoprotein MIC26 is a bona fide subunit of the MICOS complex. PMID: 25764979
2. It is likely that apoO participates in fatty acid metabolism and the inflammatory response in HepG2 cells. PMID: 24341743
3. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility. PMID: 24743151
4. relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects and patients with established acute coronary syndrome PMID: 22693255
5. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein PMID: 16956892
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亞細胞定位：

Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane.
蛋白家族：

Apolipoprotein O/MICOS complex subunit Mic27 family
組織特異性：

Expressed in all tissues examined. Up-regulated in diabetic heart.
數據庫鏈接：

HGNC: 28727

OMIM: 300753

KEGG: hsa:79135

STRING: 9606.ENSP00000368528

UniGene: Hs.495851

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