APC2 Antibody

中文名稱：

APC2兔多克隆抗體
貨號：

CSB-PA001895LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of A549 cells with CSB-PA001895LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) APC2 Polyclonal antibody
Uniprot No.：

O95996
基因名：

APC2
別名：

Adenomatous polyposis coli protein 2 antibody; Adenomatous polyposis coli protein-like antibody; APC-like antibody; apc2 antibody; APC2_HUMAN antibody; APCL antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，APC2 Antibody (CSB-PA001895LA01HU)，的標記方式是Non-conjugated。對于APC2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001895LB01HU	APC2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001895LC01HU	APC2 Antibody, FITC conjugated
Biotin	CSB-PA001895LD01HU	APC2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.
基因功能參考文獻：
1. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. PMID: 30018294
2. double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. PMID: 29101731
3. APC2 3'-UTR is targeted by hsa-miR-11181. PMID: 29111205
4. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium PMID: 27694902
5. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
6. miR-939 functioned as a potential tumor promoter by regulating the Wnt/beta-catenin signal pathway through direct suppression of APC2 expression. PMID: 25960217
7. We report that APC-2 gene is hypermethylated in both RB tumor samples and Y79 cells. Reduced APC-2 lead to increased Wnt signaling pathway protein, beta-catenin suggesting tumor suppressive role of APC-2 gene. PMID: 25207834
8. APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation. PMID: 23840886
9. These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. PMID: 22513088
10. Familial adenomatous polyposis with adenomatous polyposis coli gene mutation at codon 1309 entails a risk of a more aggressive phenotype; early colectomy may be indicated in children harboring this gene mutation. PMID: 18157572
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相關疾病：

Sotos syndrome 3 (SOTOS3)
亞細胞定位：

Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region.
蛋白家族：

Adenomatous polyposis coli (APC) family
組織特異性：

Widely expressed (at protein level). Specifically expressed in the CNS.
數據庫鏈接：

HGNC: 24036

OMIM: 612034

KEGG: hsa:10297

STRING: 9606.ENSP00000233607

UniGene: Hs.446376

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