APBB2 Antibody
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中文名稱：APBB2兔多克隆抗體
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貨號：CSB-PA009249
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：APBB2
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別名：Amyloid beta (A4) precursor protein-binding; family B; member 2 (Fe65 like) antibody; Amyloid beta A4 precursor protein binding family B member 2 antibody; Amyloid beta A4 precursor protein-binding family B member 2 antibody; APBB 2 antibody; APBB2 antibody; APBB2_HUMAN antibody; Fe65 like 1 antibody; Fe65 like antibody; Fe65 like protein antibody; FE65L 1 antibody; FE65L antibody; FE65L1 antibody; Protein Fe65-like 1 antibody; Rirl 1 antibody; Rirl1 antibody; TR2 L antibody; TR2L antibody; Zfra antibody; Zinc finger like protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human Fe65L.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength. Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Activates transcription of APP.
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基因功能參考文獻：
- APBB2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
- results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease PMID: 26194614
- The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability. PMID: 23384821
- FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles PMID: 14527950
- rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility. PMID: 15714520
- the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF PMID: 16083851
- In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1. PMID: 17567906
- The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range. PMID: 18852029
- The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell. PMID: 19542221
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亞細胞定位：Endoplasmic reticulum. Golgi apparatus. Early endosome.
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組織特異性：Widely expressed.
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數據庫鏈接：
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