APBA1 Antibody

說明書

中文名稱：

APBA1兔多克隆抗體
貨號(hào)：

CSB-PA583474
規(guī)格：

￥1100
圖片：
Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: CSB-PA583474(APBA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
其他：

產(chǎn)品詳情
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靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q02410
基因名：

APBA1
別名：

Adapter protein X11 alpha antibody; Adapter protein X11alpha antibody; Amyloid beta A4 precursor protein-binding family A member 1 antibody; Apba1 antibody; APBA1_HUMAN antibody; Mint 1 antibody; Mint-1 antibody; Neuron specific X11 protein antibody; Neuron-specific X11 protein antibody; Neuronal Munc18 1 interacting protein 1 antibody; Neuronal Munc18-1-interacting protein 1 antibody; UROP11 antibody; x11 antibody; X11alpha antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human APBA1
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
基因功能參考文獻(xiàn)：
1. Mint1 causes amyloid precursor protein accumulation in the trans-Golgi network. PMID: 26865271
2. Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
3. Mint1 826 bridges APP to the small GTPase PMID: 23737971
4. an autoinhibitory mechanism in Mint1 is important for regulating APP processing and may provide novel therapies for Alzheimer's disease PMID: 22355143
5. Transcriptional co-activators Taz and Yap mediate signaling via the amyloid beta protein precursor paralogues APLP1 and APLP2 through interactions with Mint1 and Mint3. PMID: 21178287
6. Study identified the conserved binding site for the peptide on the CASK calmodulin kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding. PMID: 21763699
7. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis. PMID: 20531236
8. Methylation of MINT1 was significantly more prevalent in UC-CRC cases compared with controls. PMID: 20160714
9. ApoEr2 regulates cell movement, and both X11alpha and Reelin enhance this effect. PMID: 19720620
10. A novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of amyloid precursor protein (APP)-interacting proteins Mint1, Mint2, and Mint3 is reported, with multiple novel interactors for these proteins. PMID: 20016085
11. Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion. PMID: 12016213
12. Coexpression of X11alpha with amyloid protein precursor retarded its maturation, prolonged its half-life, and inhibited amyloid protein precursor, Abeta40, and Abeta42 secretion. PMID: 12849748
13. human X11alpha inhibits Abeta production and deposition in vivo in the brain in transgenic mice harboring a familial Alzheimer's disease mutant APP that produces increased levels of Abeta. PMID: 12970358
14. Involvement of X11L in the phosphorylation of APP family proteins in cellular stress and suggest that X11L protein may be . PMID: 14970211
15. X11alpha and X11beta have roles in beta-amyloid precursor protein processing PMID: 15699037
16. Mediates exocytosis and decreases beta-amyloid peptide formation in Alzheimer disease. PMID: 16413130
17. Data show that neuronal munc18-1-interacting protein 1 is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. PMID: 18836734
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亞細(xì)胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Only about 5% of the protein is located in the nucleus.; [Isoform 2]: Golgi apparatus.
組織特異性：

Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.
數(shù)據(jù)庫鏈接：

HGNC: 578

OMIM: 602414

KEGG: hsa:320

STRING: 9606.ENSP00000265381

UniGene: Hs.171939

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