AMOTL2 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AMOTL2 Polyclonal antibody
Uniprot No.：

Q9Y2J4
基因名：

AMOTL2
別名：

AMOL2_HUMAN antibody; Amotl2 antibody; angiomotin like 2 antibody; Angiomotin-like protein 2 antibody; KIAA0989 antibody; LCCP antibody; Leman coiled coil protein antibody; Leman coiled-coil protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Peptide sequence from Human Angiomotin-like protein 2 protein (718-737AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AMOTL2 Antibody (CSB-PA809099NA01HU)，的標記方式是Non-conjugated。對于AMOTL2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA809099NB01HU	AMOTL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA809099NC01HU	AMOTL2 Antibody, FITC conjugated
Biotin	CSB-PA809099ND01HU	AMOTL2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
基因功能參考文獻：
1. these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention PMID: 28368415
2. AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients. PMID: 25080976
3. These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process. PMID: 23525008
4. AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ. PMID: 23911299
5. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells PMID: 21937427
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亞細胞定位：

Recycling endosome.
蛋白家族：

Angiomotin family
數據庫鏈接：

HGNC: 17812

OMIM: 614658

KEGG: hsa:51421

STRING: 9606.ENSP00000249883

UniGene: Hs.426312

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