ALKBH2 Antibody
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中文名稱：ALKBH2兔多克隆抗體
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貨號：CSB-PA761219ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 antibody at 2μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 30, 18 kDa
Observed band size: 30 kDa -
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA761219ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA761219ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ALKBH2 Polyclonal antibody
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Uniprot No.：
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基因名：ALKBH2
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別名：2OG Fe(II) oxy DC1 antibody; 9530023G02 antibody; ABH 2 antibody; ABH2 antibody; alkB alkylation repair homolog 2 antibody; ALKB2_HUMAN antibody; ALKBH2 alkB antibody; ALKBH2 antibody; Alkylated DNA repair protein alkB homolog antibody; Alkylated DNA repair protein alkB homolog 2 antibody; Alkylation repair homolog 2 antibody; Alpha ketoglutarate dependent dioxygenase alkB homolog 2 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 antibody; AU016977 antibody; DNA oxidative demethylase ALKBH2 antibody; EC 1.14.11. antibody; FLJ99103 antibody; hABH2 antibody; mABH2 antibody; MGC90512 antibody; Oxy DC1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human DNA oxidative demethylase ALKBH2 protein (1-261AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:200-1:1000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
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基因功能參考文獻：
- These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells. PMID: 26930515
- studies reveal the ALKBH2 binding interface of PCNA and indicate that both germline and somatic ALKBH2 variants could have cellular effects on ALKBH2 function in DNA repair. PMID: 26408825
- It was shown for first time that DNA glycosylase ALKBH2 can repair DNA adduct 1,N2-ethenoguanine. PMID: 25797601
- ABH2 knockdown impairs rDNA transcription and leads to increased single-stranded and double-stranded DNA breaks in the rDNA genes. PMID: 23972994
- Overexpression of ALKBH2 is associated with enhanced resistance to temozolomide in glioblastoma. PMID: 23258843
- ALKBH2 is an upstream molecule of the oncoprotein, MUC1, and regulates cell cycle and EMT, resulting in progression of urothelial carcinomas. PMID: 23279696
- combination of duplex interrogation and oxidation chemistry allows ALKBH2 to detect and process diverse lesions efficiently and correctly PMID: 22659876
- The non-enzymatic binding of AAG to 3,N(4)-ethenocytosine specifically blocks ALKBH2-catalyzed repair of 3,N(4)-ethenocytosine but not that of methylated ALKBH2 substrates. PMID: 22079122
- X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2 PMID: 21510633
- ABH2 is downregulated in a subset of gastric cancers, and might be involved in the molecular mechanism of gastric cancer through inhibiting the proliferation of gastric cancer cells. PMID: 21155885
- This work has provided a detailed understanding of the structural features of the single-stranded DNA and double-stranded DNA preferences of ABH2 and ABH3. PMID: 20714506
- Divergent sequences outside of the active site determine substrate specificities of ABH2. PMID: 20525795
- Tumour protein (TP53) is directly involved by binding to the promoter of ALKBH2 in mediating photofrin-mediaated photodynamic therapy in U87 glioma cells. PMID: 20661249
- first crystal structure of ABH2 PMID: 18432238
- ABH2 is active in the direct reversal of epsilon A lesions, and that ABH2, together with the alkyl-N-adenine-DNA glycosylase, which is the most effective enzyme for the repair of epsilon A, comprise the cellular defense against epsilon A lesions PMID: 18519673
- Mutations of ABH2 is associated with pediatric brain tumors. PMID: 19290481
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亞細胞定位：Nucleus. Note=Detected in replication foci during S-phase.
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蛋白家族：AlkB family
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組織特異性：Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
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數據庫鏈接：
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