ALG1 Antibody

說明書

中文名稱：

ALG1兔多克隆抗體
貨號：

CSB-PA887118ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA887118ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ALG1 Polyclonal antibody
Uniprot No.：

Q9BT22
基因名：

ALG1
別名：

4-mannosyltransferase antibody; Alg1 antibody; ALG1_HUMAN antibody; asparagine-linked glycosylation 1 homolog (yeast; beta-1,4-mannosyltransferase) antibody; asparagine-linked glycosylation 1; beta-1,4-mannosyltransferase homolog (S. cerevisiae) antibody; Asparagine-linked glycosylation protein 1 homolog antibody; Beta 1 4 mannosyltransferase antibody; Beta-1 antibody; CDG1K antibody; Chitobiosyldiphosphodolichol beta-mannosyltransferase antibody; GDP Man GlcNAc2 PP dolichol mannosyltransferase antibody; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase antibody; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase antibody; Hmat-1 antibody; HMAT1 antibody; HMT 1 antibody; HMT1 antibody; Mannosyltransferase 1 antibody; Mannosyltransferase-1 antibody; MT 1 antibody; MT-1 antibody; MT1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Chitobiosyldiphosphodolichol beta-mannosyltransferase protein (215-464AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
基因功能參考文獻：
1. evaluated the genetic association of WDR3 and ALG1 in schizophrenia. We examined 21 single nucleotide polymorphisms [SNPs; W1 (rs1812607)-W16 (rs6656360), A1 (rs8053916)-A10 (rs9673733)] from these genes using the Japanese case-control sample (1,808 schizophrenics and 2,170 matched controls). No significant genetic associations of these SNPs were identified. However, we detected a significant association of W4 (rs319471) PMID: 29309433
2. Study presents molecular, clinical and biochemical findings in the largest collection of ALG1-CDG cases ever reported at a single time with 39 cases, bringing the total number to 57. This ranks it the third most common CDG type behind PMM2-CDG and ALG6-CDG. In addition, highly lethal genotype were identified and confirm the presence of a unique xeno-tetrasaccharide in ALG1-CDG patients. PMID: 26931382
3. In title. PMID: 25649379
4. Was detected in the patient's ALG1-coding sequence. PMID: 24157261
5. Family study defining the phenotype of deficiency of beta-1,4 mannosyltransferase (MT-1) congenital disorder of glycosylation (CDG), due to ALG1 gene mutations. Four novel ALG1 mutations were identified. PMID: 22966035
6. DNA sequencing of ALG1 revealed nine different mutations, seven of which have not been previously reported. Clinical presentations of deficiency are severe, with dysmorphias, CNS involvement and ocular disturbances PMID: 20679665
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相關疾病：

Congenital disorder of glycosylation 1K (CDG1K)
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase group 1 family, Glycosyltransferase 33 subfamily
數據庫鏈接：

HGNC: 18294

OMIM: 605907

KEGG: hsa:56052

STRING: 9606.ENSP00000262374

UniGene: Hs.592086

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