ALDH3A1 Antibody
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中文名稱：ALDH3A1兔多克隆抗體
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貨號：CSB-PA001572EA01HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: ALDH3A1 antibody at 2µg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51 kDa
Observed band size: 51 kDa -
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA001572EA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001572EA01HU at dilution of 1:100 -
Immunofluorescence staining of A549 cells with CSB-PA001572EA01HU at 1:120,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ALDH3A1 Polyclonal antibody
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Uniprot No.：
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基因名：ALDH3A1
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別名：Acetaldehyde dehydrogenase 3 antibody; AHD 4 antibody; AHD C antibody; AHD4 antibody; AHDC antibody; AL3A1_HUMAN antibody; Aldehyde dehydrogenase 3 antibody; Aldehyde dehydrogenase 3 family member A1 antibody; Aldehyde dehydrogenase 3A1 antibody; Aldehyde dehydrogenase antibody; Aldehyde dehydrogenase class 3 antibody; Aldehyde dehydrogenase dimeric NADP preferring antibody; Aldehyde dehydrogenase family 3 member A1 antibody; Aldehyde dehydrogenase family 3 subfamily A1 antibody; Aldehyde dehydrogenase family 3, subfamily A, member 1 antibody; Aldehyde dehydrogenase isozyme 3 antibody; Aldehyde dehydrogenase type III antibody; ALDH 3 antibody; ALDH 3A1 antibody; ALDH III antibody; ALDH, stomach type antibody; ALDH3 A1 antibody; ALDH3 antibody; ALDH3A 1 antibody; Aldh3a1 antibody; ALDHIII antibody; dimeric NADP-preferring antibody; MGC10406 antibody; Stomach aldehyde dehydrogenase antibody; Tumor associated aldehyde dehydrogenase tumor ALDH antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring protein (210-453AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，ALDH3A1 Antibody (CSB-PA001572EA01HU)，的標(biāo)記方式是Non-conjugated。對于ALDH3A1 Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:200-1:2000 IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻(xiàn)
- Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells Jin Won Park.et al,Oncotarget,2017
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
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基因功能參考文獻(xiàn)：
- ALDH3A1 appears to play an essential role in protecting cellular proteins against aggregation under stress conditions PMID: 28526614
- ALDH3A1 confers a multi-modality resistance phenotype in MCF-7 cells PMID: 27276244
- Molecular docking analysis depicted that Sulforaphane fits into the active site of ALDH3A1, and facilitates the catalytic mechanism of the enzyme. PMID: 27997560
- ALDH-3A1 expression correlates well with gastric cancer dysplasia and grades, differentiation, lymph node metastasis and cancer stage. PMID: 27279633
- Down-regulation of ALDH3 activity in trophoblast stem cells initiates trophoblast differentiation during placental development. PMID: 26124079
- ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms PMID: 26751691
- Reported increased expression of ALDH3A1, PDIA3, and PRDX2 in pterygia using a proteomic approach. These proteins are presumed to have a protective role against oxidative stress-induced apoptosis. PMID: 25221425
- SiRNA-mediated suppression of ALDH3A1 blocked ALDH enzymatic activity and augmented cytotoxicity in CSE-exposed cells. PMID: 24316006
- While ALDH3A1 was not found in prostate glands, it was present in prostatic intraepithelial neoplasia, further increased in carcinomas, and upregulated in lymphatic metastases. ALDH3A1 increased in DU145-cell-derived lung metastasis vs. local xenografts. PMID: 24762960
- No correlation between ALDH3A1 expression and patient survival or tumour recurrence was observed.In conclusion, ALDH3A1 is a marker of activation of the Wnt/ss-catenin pathway in hepatocellular carcinoma PMID: 24276407
- ALDH3A1 provides exceptional protection from the adverse effects of pathophysiological concentrations of 4-HNE such as may occur during periods of oxidative stress PMID: 22406320
- through modulation of PPARgamma or ALDH3A1, it may be possible to reduce cell proliferation in tumor cells or stimulate cell proliferation in normal cells during tissue regeneration. PMID: 21251908
- the UV-induced inactivation of ALDH3A1 is a result of non-native aggregation and associated structural changes rather than specific damage to the active site Cys PMID: 21203538
- Antihypertensives, nonopioid analgesics and hormonal contraceptives significantly affect the salivary ALDH3A1 activity. PMID: 21229876
- These findings suggest that a high level of expression of ALDH3 in cancerous liver tissues resulted from the expression or activation of at least two nuclear proteins reacting to the ALDH3 promoter region. PMID: 9855707
- ADH3*1 allele associated with high ADH activity and acetyaldehyde-DNA adducts in lung; may be a risk factor for lung cancer PMID: 12367788
- ALDH3A1 is a regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage PMID: 12706498
- Enzyme activity and localization of ALDH3A1 in the cornea. PMID: 12943535
- ALDH3A1 may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle PMID: 15905174
- In most cases, ALDH3A1 activity in tumor and bordering tissues was higher than in a control group PMID: 18536178
- the mechanism of salivary ALDH3A1 inactivation must be related to free radical activity, presumably in the salivary gland, but it is not simply correlated with antioxidatn capacity of saliva PMID: 19894643
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：Aldehyde dehydrogenase family
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組織特異性：High levels in stomach, esophagus and lung; low level in the liver and kidney.
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