欧美多毛肥妇视频-国产成人免费在线观看-99久久无码一区人妻a片潘金莲-免费视频一二三区-久久久夜色精品-女人大荫蒂毛茸茸视频-久久99精品久久久久久琪琪-国产91勾搭技师精品-亚洲乱码日产精品bd-欧州一区二区-一本色道av久久精品+-日韩看片-国产视频第一页-东北女人啪啪对白-一品毛片-91福利在线免费观看-欧美一级片毛片-亚洲精品乱码久久久久久-五月六月婷婷-国产在线 | 中文

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AKR1A1 Antibody

AKR1A1 Antibody

  • 中文名稱：
    AKR1A1兔多克隆抗體
  • 貨號：
    CSB-PA001538LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, Mouse stomach tissue
      All lanes: Akr1a1 antibody at 2.8μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 37 kDa
      Observed band size: 37, 23 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001538LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA001538LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) AKR1A1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AKR1A1
  • 別名：
    AK1A1_HUMAN antibody; Akr1a1 antibody; Alcohol dehydrogenase [NADP+] antibody; Alcohol dehydrogenase antibody; Aldehyde reductase antibody; Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody; Aldo-keto reductase family 1 member A1 antibody; ALDR1 antibody; ALR antibody; ARM antibody; DD3 antibody; MGC12529 antibody; MGC1380 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Alcohol dehydrogenase [NADP(+)] protein (2-325AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，AKR1A1 Antibody (CSB-PA001538LA01HU)，的標記方式是Non-conjugated。對于AKR1A1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001538LB01HU AKR1A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA001538LC01HU AKR1A1 Antibody, FITC conjugated
    Biotin CSB-PA001538LD01HU AKR1A1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.
  • 基因功能參考文獻：
    1. Data (including data from studies in knockout and transgenic mice) suggest that AKR1A1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
    2. prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
    3. AKR1A1 could be involved in the metabolism of 4-hydroxynonenal and play a role in the resistance to oxidative stress PMID: 23643085
    4. AKR1A1 has little effect on the production of gamma-hydroxybutyrate PMID: 21276435
    5. structure of Apo R268A human aldose reductase reveals hinges and latches that control the kinetic mechanism PMID: 15769597
    6. the binding site residues deviating between ALR1 and ALR2 influence ligand affinity in a complex interplay, presumably involving changes of dynamic properties and differences of the solvation/desolvation balance upon ligand binding PMID: 18495158

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Apical cell membrane.
  • 蛋白家族：
    Aldo/keto reductase family
  • 組織特異性：
    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 數據庫鏈接：

    HGNC: 380

    OMIM: 103830

    KEGG: hsa:10327

    STRING: 9606.ENSP00000312606

    UniGene: Hs.474584