AKAP5 Antibody
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中文名稱：AKAP5兔多克隆抗體
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貨號：CSB-PA000843
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規格：￥1090
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圖片：
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Western Blot analysis of COLO205 cells using AKAP 79 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：AKAP5
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別名：A kinase (PRKA) anchor protein 5 antibody; A kinase anchor protein 5 antibody; A kinase anchor protein 79kDa antibody; A kinase anchoring protein 75/79 antibody; A-kinase anchor protein 5 antibody; A-kinase anchor protein 79 kDa antibody; AKAP 5 antibody; AKAP 75 antibody; AKAP 79 antibody; AKAP-5 antibody; Akap5 antibody; AKAP5_HUMAN antibody; AKAP75 antibody; AKAP79 antibody; cAMP dependent protein kinase regulatory subunit II high affinity binding protein antibody; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein antibody; H21 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the N-terminal region of Human AKAP 79.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses.
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基因功能參考文獻：
- results provide the first direct evidence for a function of the well-described AKAP79/150 trafficking in regulating LTD-induced spine shrinkage. PMID: 29196604
- We determined a crystal structure of CaM bound to a peptide encompassing its binding site in AKAP79. CaM adopts a highly compact conformation in which its open Ca(2+)-activated C-lobe and closed N-lobe cooperate to recognize a mixed alpha/310 helix in AKAP79. PMID: 29162807
- A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies. PMID: 28967377
- Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 region of the hippocampus. PMID: 27911714
- Cigarette smoke-induced changes in AKAP5 and AKAP12 in patients with COPD may affect efficacy of pharmacotherapy. PMID: 25637608
- human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330 PMID: 25882844
- GPR30 interacted with membrane-associated guanylate kinases and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a PDZ-dependent manner. PMID: 24962572
- a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells. PMID: 24121510
- Patients with bipolar disorder have higher density of AKAP5-expressing neurons in the anterior cingulate cortex compared with controls. PMID: 23462372
- AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. PMID: 23889134
- AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli. PMID: 23383244
- Antagonizing the interaction between AKAP79 and TRPV1 inhibits inflammatory hyperalgesia. PMID: 23616546
- AKAP79 directly interacts with Cav1.2 c-terminus and modulates Cav1.2 membrane targeting. PMID: 22677788
- results reveal novel roles for the AKAP79/150 signaling complex in dendritic endosomes. PMID: 22623657
- show that an IAIIIT anchoring site in human AKAP79 binds the same surface of calcineurin as the PxIxIT recognition peptide of NFAT, albeit more strongly PMID: 22343722
- Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8. PMID: 21771783
- AKAP79 may be the key AKAPs responsible for regulating antigen presentation. PMID: 21221125
- dimeric AKAP79 concentrates pockets of second messenger responsive enzyme activities at the plasma membrane. PMID: 21464287
- by favoring apoCaM binding to AKAP79, KN-62 and KN-93 derail the ability of AKAP79 to efficiently recruit PKC for regulation of GluA1. Thus, AKAP79 endows PKC with a pharmacological profile that overlaps with CaMKII. PMID: 21156788
- Studies indicate that the cAMP signaling pathway is organized by A-kinase anchoring proteins and AKAP79 remainis the best-understood anchoring protein. PMID: 20883492
- Data reveal that an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events. PMID: 20410303
- that during prenatal development AKAP79 expression increased gradually in the red nucleus PMID: 12077483
- Trafficking of L-type calcium channels is mediated by the postsynaptic scaffolding protein AKAP79. PMID: 12114507
- AKAP79 has a role in organizing large signalling complexes PMID: 12507994
- there is a 13-amino acid region within CN that is essential for the interaction with NFAT and with two other CN-binding proteins, AKAP79 and Cabin-1 PMID: 15671033
- AKAP79 provides cyclic AMP-dependent protein kinase to phosphorylate the beta1-adrenergic receptor and thereby dictate the recycling and resensitization itineraries of the beta1-adrenergic receptor PMID: 16940053
- AKAP79 interacts with adenylyl cyclase V and adenylyl cyclase VI in a complex that associates with protein kinase A forming a negative feedback loop that termporally regulates cAMP production. PMID: 16973443
- AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a, and calcineurin regulates ASIC1a and ASIC2a activity PMID: 17548344
- AKAP79 provides a mechanism to overcome limitations in kinase abundance thereby ensuring faithful signal propagation and efficient modification of AMPA receptor-mediated responses PMID: 18305116
- AKAP5 protein is associated with its G-protein-coupled receptor, at the cell membrane, docked with the receptor during agonist-induced internalization and later receptor recycling after agonist wash-out. PMID: 18950703
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亞細胞定位：Postsynaptic recycling endosome membrane; Lipid-anchor.
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組織特異性：Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
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數據庫鏈接：
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