AFAP1L2 Antibody
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中文名稱：AFAP1L2兔多克隆抗體
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貨號：CSB-PA001410GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：AFAP1L2
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別名：Actin filament-associated protein 1-like 2 antibody; AF1L2_HUMAN antibody; AFAP1-like protein 2 antibody; afap1l2 antibody; CTB-1144G6.4 antibody; KIAA1914 antibody; XB130 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human AFAP1L2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
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基因功能參考文獻：
- present study demonstrated that the expression of XB130 is elevated in CRC cells. Loss of XB130 was associated with decreased invasion and migration of CRC cells, possibly as a result of EMT inhibition. PMID: 28849225
- Our results suggest that dissociation between XB130 and Tks5 may facilitate lateral cell migration via XB130/Rac1, and vertical cell migration via Tks5/Cdc42. These molecular mechanisms will help our understanding of airway epithelial repair and regeneration. PMID: 27835612
- these observations suggest that XB130 may be a novel molecular marker and potent therapeutic target for prostate PMID: 27509056
- Results suggest that Tks5, similar to XB130, plays a role in cell proliferation and cell survival and that the interaction between XB130 and Tks5 appears to be critical for regulation of Src-mediated cellular homeostasis. PMID: 26446840
- XB130 is a mediator for nicotine-derived nitrosamine ketone-induced cell migration through its translocation to cell motility related microfilamentous cellular structures. PMID: 25980441
- XB130 could be useful as a prognostic marker of recurrence-free and overall survival in invasive ductal breast cancer, as well as for the response to chemotherapy. PMID: 26191231
- This is the first study to reveal that XB130 overexpression may be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients PMID: 26045762
- Results showed significant interaction between variants at TERF1 and AFAP1L2 loci. Given the key role of TERF1 in telomere biology and its physical interaction with AFAP1L2, these results support a role for telomere dysfunction in melanoma development. PMID: 25892537
- High XB130 expression is associated with pancreatic ductal adenocarcinoma. PMID: 24581082
- XB130 enhances cell motility and invasiveness by modulating the epithelial-mesenchymal transition-like process. PMID: 24387290
- High nuclear expression of XB130 is associated with esophageal squamous cell carcinoma. PMID: 22805860
- XB130 could promote growth of cancer cells by regulating expression of tumor suppressive miRNAs and their targeted genes. PMID: 23527086
- XB130 is a substrate of multiple protein tyrosine kinases, and it can regulate cell proliferation and survival through modulating selected down-stream signals of PI3K/Akt pathway PMID: 22928011
- reduced XB130 protein expression is a prognostic biomarker for shorter survival and a higher recurrence rate in patients with gastric cancer PMID: 22927913
- Protein expression of XB130 is not associated with the postoperative prognosis of patients with hepatocellular carcinoma. PMID: 22190283
- These observations suggest that the expression of XB130 in these cancer cells may affect cell proliferation and survival by controlling the expression of multiple genes, especially transcription regulators. PMID: 21224076
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亞細胞定位：Cytoplasm.
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組織特異性：Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas.
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數據庫鏈接：
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