ADHFE1 Antibody

說明書

中文名稱：

ADHFE1兔多克隆抗體
貨號：

CSB-PA654216
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA654216(ADHFE1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA654216(ADHFE1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情

Uniprot No.：

Q8IWW8
基因名：

ADHFE1
別名：

ADH8 antibody; ADHFE 1 antibody; ADHFe1 antibody; Alcohol dehydrogenase iron-containing protein 1 antibody; Alcohol dehydrogenase; iron containing; 1 antibody; Fe containing alcohol dehydrogenase antibody; Fe-containing alcohol dehydrogenase antibody; HOT antibody; HOT_HUMAN antibody; Hydroxyacid oxoacid transhydrogenase; mitochondrial antibody; Hydroxyacid-oxoacid transhydrogenase antibody; mitochondrial antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human ADHFE1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
基因功能參考文獻：
1. These results demonstrate that the promoter hypermethylation of ADHFE1 is frequently present in CRC and alcohol induces methylation-mediated down expression of ADHFE1 and proliferation of CRC cells. PMID: 24886599
2. ADHFE1 has an important role of differentiation in CRC, as well as normal colorectal mucosa and embryonic developmental processes. PMID: 23517143
3. cloned and characterized an iron-activated alcohol dehydrogenase gene, Fe-containing alcohol dehydrogenase 1 (ADHFe1) PMID: 12592711
4. show that the ADHFe1 gene is related to bacterial GHB dehydrogenases and has a conserved NAD-binding site PMID: 19013439
亞細胞定位：

Mitochondrion.
蛋白家族：

Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
組織特異性：

Only expressed in adult liver.
數據庫鏈接：

HGNC: 16354

OMIM: 611083

KEGG: hsa:137872

STRING: 9606.ENSP00000379865

UniGene: Hs.720023

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