ACSL6 Antibody, HRP conjugated
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中文名稱：ACSL6兔多克隆抗體, HRP偶聯
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貨號：CSB-PA892139LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ACSL6 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6), ACSL6, ACS2 FACL6 KIAA0837 LACS5
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Long-chain-fatty-acid--CoA ligase 6 protein (214-484aa)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
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基因功能參考文獻：
- ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation PMID: 27647415
- variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked PMID: 22205969
- The alternative fatty acid Gate-domain motifs are essential determinants for the activity of the human ACSL6 isoforms, which appear to act as homodimeric enzyme as well as in complex with other spliced forms. PMID: 20429931
- The t(5;12)(q23-31;p13)translocation with ETV6-ACSL6 genomic alteration rearrangement in polycythemia vera patients was reported. PMID: 16572202
- Analyses did not yield convincing evidence for associations of schizophrenia with ACSL6 PMID: 16827919
- Three ACSL6 spliced variants of a mutually exclusive exon pair are reported, they encode a slightly different short motif which contains a conserved structural domain, the fatty acid Gate domain. PMID: 16834775
- haplotypes underlying the SPEC2/PDZ-GEF2/ACSL6 region are associated with schizophrenia PMID: 17030554
- The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes. PMID: 18555221
- ACSL6 is highly associated with schizophrenia and several haplotypes in this haploblock have about twofold to 10-fold increase in the affected subjects in Han Chinese. PMID: 18718982
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相關疾病：A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.
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亞細胞定位：Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
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蛋白家族：ATP-dependent AMP-binding enzyme family
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組織特異性：Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
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數據庫鏈接：
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