Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA14579A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA14579A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA14579A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
基因功能參考文獻:
Serum alpha2MG levels might reflect endothelial dysfunction evaluated by flow-mediated dilation in patients with chronic stroke or cardiovascular risk factors PMID: 29093276
The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3, may be an important protein in the pathogenesis of allergic rhinitis in AR patients. PMID: 27228572
Proteomics study showed a strong association of FN1, A2M, C4BPA and CFB in molecular subtypes of breast cancer, in which, C4BPA and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB) and Triple-negative (TN)subtypes in BC patients, respectively. PMID: 27498393
BBB disruption is present in ACS, and elevated levels of IL-6 and C3 in CSF in diffuse NPSLE PMID: 29036223
Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants. PMID: 28705706
The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ... PMID: 28087279
Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control. PMID: 28215695
Data show that low that low globulin (GLB) levels were significantly associated with favorable survival, and low ALB levels were associated with a significantly worse survival . PMID: 26476541
This work demonstrates that alpha2M*/CS-GRP78 acts as an upstream regulator of the PDK1/PLK1 signaling axis to modulate c-MYC transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC-associated malignant progression. PMID: 27002159
Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease. PMID: 25495992
These data demonstrate that alpha2M* and LRP1 modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2+)dynamics in hMSMCs during pregnancy. PMID: 27044074
we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins PMID: 26134405
A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M. PMID: 25809189
Data indicate that the expression of salivary alpha2 macroglobulin (alpha2-M) showed a remarkable increase in type 2 diabetes mellitus (T2DM), which may be associated with functional disorders of the salivary gland. PMID: 25867373
A2M is not the only biological candidate gene for AD determination PMID: 25574746
Alpha2M causes neurodegeneration in a p75(NTR)- and proNGF-dependent manner. PMID: 26217017
there is no enough evidence for associations of A2M gene polymorphisms (5 bp I/D, Ile1000Val) with Alzheimer's disease risk PMID: 24756728
phosphorylating the T-loop Akt residue Thr(308) by PDK1 requires Raptor of the mTORC1 complex as a platform or scaffold protein. PMID: 24516643
genetic variation within the A2M gene influences CSF Ab42 levels. PMID: 24011543
alpha2M is a specialized chaperone that prevents the extracellular accumulation of misfolded and potentially pathogenic proteins, particularly during innate immune system activity PMID: 24799681
FEIgG and alpha2m/C are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide; their predictive value, if validated in prospective studies, may be useful in clinical practice PMID: 24093110
There is no statistically significant difference in allele or genotype frequencies between patients with sporadic Alzheimer's disease and control subjects for the A2M polymorphism. PMID: 23186781
Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, alpha2M and CP as well as CysLT may be involved in eosinophilic inflammation. PMID: 23786280
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. PMID: 23846698
alpha2macroglobulin stimulates endothelial and early cardiac muscle differentiation of embryonic stem cells through generation of induction of FGF-2 expression. PMID: 23379699
Serum monomeric alpha2-macroglobulin is highly expressed in many diabetic subjects. PMID: 23535567
While activated alpha-2-microglobulin (AA2M) ligates only one GRP78 receptor molecule per AA2M, it may potentially serve as a reservoir for release of up to four binding fragments per molecule. PMID: 23721263
Oxidative stress and the levels of endogenous plasma prolyl oligopeptidase (PREP) inhibitor alpha-2-macroglobulin (alpha2M) decrease PREP activity in patients with multiple sclerosis. PMID: 23643808
IGFBP-2 associates with alpha2-macroglobulin in the blood circulation. PMID: 23397525
[review] alpha2M has many diversified and complex functions but is primarily known by its ability to inhibit a broad spectrum of proteases without the direct blockage of the protease active site. PMID: 23086799
protease-activated alpha2M has two mechanisms for inhibiting amyloid formation: via protease-alpha2M-mediated degradation of amyloidogenic substrates and by a chaperone action that prevents misfolded clients from continuing along the amyloid forming pathway. PMID: 23353684
inhibitory activity of Aeromonas sobria serine protease by alpha2-macroglobulin PMID: 23089609
Complexes between alpha2-macroglobulin and urokinase were detected in alveolar edema fluids as well as in lungs of patients with acute lung injury/acute respiratory distress syndrome where they were located mainly in close proximity to epithelial cells. PMID: 23064953
an isoform of ASP cleaved proteins more in plasma and was inhibited by human alpha(2)-macroglobulin more slowly than single-chain ASP PMID: 22971340
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma PMID: 22541546
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients PMID: 22576683
Ethnicity affects the genetic association of A2M with rheumatoid arthritis in South Asian and Caucasian patients living in East Midlands/United Kingdom. PMID: 20401725
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid PMID: 21971609
Identify a novel transcriptional regulatory element contributing to the up-regulation of alpha2M during replicative senescence. PMID: 21541797
alpha2-macroglobulin is neurotoxic by inhibiting neuroprotective activity of nerve growth factor via TrkA receptors. PMID: 21642630
dimeric alpha2M as well as tetrameric alpha2M may play an important role in controlling beta2-m amyloid fibril formation PMID: 21216953
The chaperone action of alpha-2-macroglobulin targets prefibrillar species to inhibit amyloid formation PMID: 19074141
The chaperone action of alpha-2-macroglobulin inhibits the toxicity and uptake of A beta in human cerebrospinal fluid PMID: 19472074
The extracellular chaperone alpha-2-macroglobulin is likely to help control amyloid formation and toxicity in vivo PMID: 18075673
Alpha-2-macroglobulin is an extracellular chaperone PMID: 18171086
statistically significant evidence of interaction between the polymorphisms in A2M, SLC6A4 and UCHL1 genes (global P = 0.0107, for the best model) and the risk for PD. PMID: 20861575
LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD. PMID: 20637261
Reduced expression of alpha-2 macroglobulin and complement factor B was detected in sera of patients with nasopharyngeal carcinoma. PMID: 20575108
Haplotype -88G/25G might play a protective role in the development of SAD, and the protective effects of -88G and 25G were independent of APOEvarepsilon4 allele. PMID: 20493925
Galectin-3 Binding Protein and Alpha-2 macroglobulin were differentially expressed on DVT patients in microparticles extracted from platelet-poor plasma PMID: 20156641
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亞細胞定位:
Secreted.
蛋白家族:
Protease inhibitor I39 (alpha-2-macroglobulin) family