Recombinant Horse Interleukin-1 Receptor Antagonist protein (IL1RN)
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中文名稱：Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)
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品名簡稱：Recombinant Horse IL1RN protein (Active)
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貨號：CSB-AP003491HO
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說明書：
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規格：￥852
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圖片：
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其他：
產品詳情
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純度：>95% as determined by SDS-PAGE.
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內毒素：Less than 1.0 EU/μg as determined by LAL method.
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生物活性：Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 3.0 μg/ml, corresponding to a specific activity of >333 IU/mg in the presence of 50 pg/ml rHuIL-1α.
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基因名：IL1RN
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Uniprot No.：
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別名：IL1RN; IL1RAInterleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor
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種屬：Equus caballus (Horse)
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蛋白長度：Full Length of Mature Protein
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來源：E.Coli
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分子量：17.4 kDa
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表達區域：26-177aa
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氨基酸序列HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ
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蛋白標簽：Tag-Free
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產品提供形式：Liquid or Lyophilized powder
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緩沖液：0.2 μm filtered PBS, pH 7.4 ,lyophilized
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：5-10 business days
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Datasheet & COA：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
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基因功能參考文獻：
- This is the first study in an equine model to establish a dosing/redosing protocol, as well as examine the Nab response to capsid and supports further clinical investigation to determine the clinical efficacy of scAAVIL-1ra to treat osteoarthritis. PMID: 25902762
- Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 signal transduction and thereby plays an important role in the establishment of equine pregnancy. PMID: 19157767
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亞細胞定位：Secreted.
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蛋白家族：IL-1 family
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數據庫鏈接：
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