Rat matrix metalloproteinase 3,MMP-3 ELISA kit

Rat matrix metalloproteinase 3,MMP-3 ELISA kit

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中文名稱：

大鼠基質(zhì)金屬蛋白酶3(MMP-3)酶聯(lián)免疫試劑盒
貨號：

CSB-E07410r
規(guī)格：

96T/48T
價格：

￥3600/￥2500
促銷：
其他：

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產(chǎn)品描述：

大鼠基質(zhì)金屬蛋白酶3(MMP-3)酶聯(lián)免疫試劑盒（CSB-E07410r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的MMP3含量。MMP3，即基質(zhì)金屬蛋白酶3，是一種在多種生理和病理過程中發(fā)揮關(guān)鍵作用的酶類分子。它在炎癥性疾病、腫瘤、動脈粥樣硬化和神經(jīng)系統(tǒng)疾病中扮演重要角色，能夠降解多種基質(zhì)成分，并激活其他MMPs，參與組織重塑和疾病進程。研究顯示，MMP3的基因多態(tài)性與某些疾病的遺傳易感性相關(guān)，如食管鱗癌。試劑盒檢測范圍為1.56 pg/mL-100 pg/mL，本產(chǎn)品可廣泛應(yīng)用于基礎(chǔ)醫(yī)學研究領(lǐng)域，如關(guān)節(jié)炎動物模型中的基質(zhì)代謝研究、藥物干預(yù)下MMP - 3表達水平動態(tài)監(jiān)測，或腫瘤微環(huán)境中蛋白酶活性評估等實驗場景，為組織重塑機制探索及病理模型構(gòu)建提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

Mmp3 ELISA Kit; Stromelysin-1 ELISA Kit; SL-1 ELISA Kit; EC 3.4.24.17 ELISA Kit; Matrix metalloproteinase-3 ELISA Kit; MMP-3 ELISA Kit; PTR1 protein ELISA Kit; Transin-1 ELISA Kit
縮寫：

MMP3
Uniprot No.：

P03957
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, cell culture supernates, tissue homogenates
檢測范圍：

1.56 pg/mL-100 pg/mL
靈敏度：

0.39 pg/mL
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Cancer
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of rat MMP-3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:100	Average %	90
	Range %	87-93
1:200	Average %	94
	Range %	90-98
1:400	Average %	95
	Range %	91-99
1:800	Average %	92
	Range %	88-96

回收率：

The recovery of rat MMP-3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	85	81-89
EDTA plasma (n=4)	94	90-98

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
100	2.569	2.547	2.558	2.429
50	2.236	2.213	2.225	2.096
25	1.868	1.829	1.849	1.720
12.5	1.367	1.387	1.377	1.248
6.25	0.840	0.889	0.865	0.736
3.13	0.377	0.387	0.382	0.253
1.56	0.247	0.259	0.253	0.124
0	0.128	0.130	0.129

數(shù)據(jù)處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

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Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain Cordaro M, et al,Arthritis Research & Therapy,2019
Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis Kamel KM, et al,Life Sciences,2019
Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund’s Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and NF-кB Kamel M. Kamel.et al,Inflammation,2018
A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models Britti D.et al,BMC Vet Res.,2017
Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats Rosanna Di Paola.et al,Arthritis Research & Therapy,2016
Matrix metalloproteinases are possible targets inmonocrotaline-induced pulmonary hypertension: investigationof anti-remodeling effects of alagebrium and everolimus Atl.et al,Anatolian journal of cardiology,2016

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功能：

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
亞細胞定位：

Secreted, extracellular space, extracellular matrix. Secreted.
蛋白家族：

Peptidase M10A family
數(shù)據(jù)庫鏈接：

UniGene: Rn.32086

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.