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中文名稱：大鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯免疫試劑盒
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貨號：CSB-E10786r
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規格：96T/48T
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價格：￥3900/￥2500
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其他：
產品詳情
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產品描述：大鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯免疫試劑盒（CSB-E10786r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的Aβ1-42含量。Aβ1-42是重要的阿爾茨海默病相關靶點。其在腦內異常聚集形成淀粉樣斑塊，被認為是該病發病的關鍵病理特征。研究聚焦于其生成、清除機制、神經毒性作用等，期望通過干預Aβ1-42代謝過程開發有效治療手段。試劑盒檢測范圍為0.9 pg/mL-60 pg/mL，適用于神經科學領域的基礎研究，如阿爾茨海默病動物模型中Aβ1 - 42的動態變化觀察、藥物干預效果評價或病理機制探索，其寬泛的樣本兼容性可滿足腦組織、血液等多種生物樣本的檢測需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Amyloid beta 42(ABeta 42),amyloid beta peptide 1-42,Aβ1-42,amyloid βpeptide 1-42
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縮寫：Aβ1-42
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.9 pg/mL-60 pg/mL
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靈敏度：0.225 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Neuroscience
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of rat Aβ1-42 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 87 Range % 83-90 1:2 Average % 94 Range % 90-98 1:4 Average % 101 Range % 97-104 1:8 Average % 96 Range % 93-99 -
回收率：
The recovery of rat Aβ1-42 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 94 89-98 EDTA plasma (n=4) 100 95-105 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 60 2.281 2.274 2.278 2.136 30 1.599 1.576 1.588 1.446 15 0.967 0.924 0.946 0.804 7.5 0.538 0.528 0.533 0.391 3.75 0.395 0.371 0.383 0.241 1.8 0.321 0.312 0.317 0.175 0.9 0.235 0.250 0.243 0.101 0 0.141 0.143 0.142 -
數據處理：
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貨期：3-5 working days
引用文獻
- The protective effects of nano-selenium particles and thymoquinone against rats' lipopolysaccharide-induced Alzheimer's disease NA Elsabbagh, DE Ellakwa,Azhar International Journal of Pharmaceutical and Medical Sciences,2025
- A high cholesterol diet accelerates Alzheimer's progression by promoting fibrotic damage in rats A Das, D Chowdhury, D Sharma, R Manna,Brain Disorders,2025
- A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer's disease DES Ellakwa, LA Rashed, OS Ali,Future Science OA,2025
- Sex-specific effects of dietary salt intake on circulating Alzheimer's disease-related biomarkers in aged rats F Sun, QX Wang, LP Zhao, Q Jin,Journal of Alzheimers Disease Reports,2025
- Curcumin-Nicotinate Attenuates Hippocampal Synaptogenesis Dysfunction in Hyperlipidemia Rats by the BDNF/TrkB/CREB Pathway: Involving Idol/LDLR Signaling to Eliminate Aβ Deposition LY Wang,Natural Product Communications,2022
- Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease A El-Aziz,Pharmaceuticals,2022
- Anti-aging trait of whey protein against brain damage of senile rats ME El-Beeh,Anti-aging trait of whey protein against brain damage of senile rats,2022
- Impact of ginseng on neurotoxicity induced by cisplatin in rats M Hussien,Advance online publication,2021
- Trichoderma reesei fungal degradation boosted the potentiality of date pit extract in fighting scopolamine-induced neurotoxicity in male rats SR Sale,Scientific Reports,2021
- Effects of Naodesheng tablets on amyloid beta-induced dysfunction: A traditional Chinese herbal formula with novel therapeutic potential in Alzheimer's disease revealed by systems pharmacology Baoyue Zhang,Biomedicine & Pharmacotherapy,2021
- Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl3-induced Alzheimer-like pathology model Rofida A. Saleh,Scientific reports,2021
- Ipriflavone and Ipriflavone loaded albumin nanoparticles reverse lipopolysaccharide induced neuroinflammation in rats NW Yassa,PLoS ONE,2020
- Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats MM Safar,Chemico-Biological Interactions,2020
- Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer\\\'s-Like Disease in Rats GI Fouad,Neurochemical Research,2020
- Gagandeep Kaur Atish Prakash, et al,The Journal of Nutritional Biochemistry,2019
- Effect of Berberine and Ipriflavone Mixture against Scopolamine-Induced Alzheimer-Like Disease Mohamed S. Abdel-Latif, et al,International Journal of Pharmaceutical and Phytopharmacological Research,2019
- The potential value of capsaicin in modulating cognitive functions in a rat model of streptozotocin-induced Alzheimer’s disease Manal A. Shalaby, et al,Febs Journal,2019
- Neuroprotective Effects of Zafirlukast, Piracetam and Their Combination on L-Methionine-Induced Vascular Dementia in Rats Fayez AM, et al,fundamental & clinical pharmacology,2019
- Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels Davar Khodadadi.et al,Neurochemical Research,2018
- Catalpol provides a protective effect on fibrillary Aβ1?42-induced barrier disruption in an in vitro model of the blood?brain barrier Liu C.et al,Phytother Res,2018
- Neuroprotective effect of berberine against environmental heavy metals-induced neurotixicity and Alzheimer\'s-like disease in rats Hend M.Hussien.et al,Food and Chemical Toxicology,2017
- Possible role of endothelin receptor against hyperhomocysteinemia and β-amyloid induced AD type of vascular dementia in rats Singh M.et al,Brain Res Bull.,2017
- Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against β-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats. Kalra J.et al,Pharmacol Biochem Behav.,2016
- Developmental perfluorooctane sulfonate exposure results in tau hyperphosphorylation and 尾-amyloid aggregation in adults rats: Incidence for link to Alzheimer's disease Zhang Q.et al,Toxicology.,2016
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