Mouse amyloid beta peptide 1-42,Aβ1-42 ELISA Kit

Mouse amyloid beta peptide 1-42,Aβ1-42 ELISA Kit

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中文名稱：

小鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯(lián)免疫試劑盒
貨號：

CSB-E10787m
規(guī)格：

96T/48T
價格：

￥3800/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產(chǎn)品描述：

小鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯(lián)免疫試劑盒（CSB-E10787m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的Aβ1-42含量。Aβ1-42是重要的阿爾茨海默病相關(guān)靶點。在患者腦內(nèi)該蛋白異常聚集形成淀粉樣斑塊，破壞神經(jīng)細(xì)胞功能與結(jié)構(gòu)。研究聚焦其產(chǎn)生、聚集過程及與神經(jīng)毒性的關(guān)聯(lián)，旨在通過抑制生成、促進(jìn)清除等機(jī)制來改善病情、研發(fā)治療藥物。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于阿爾茨海默病小鼠模型構(gòu)建、Aβ病理機(jī)制研究、藥物干預(yù)效果評估等實驗場景，為神經(jīng)科學(xué)領(lǐng)域提供可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

Amyloid beta 42(ABeta 42),amyloid beta peptide 1-42,Aβ1-42,amyloid βpeptide 1-42
縮寫：

Aβ1-42
種屬：

Mus musculus (Mouse)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

15.6 pg/mL-1000 pg/mL
靈敏度：

3.9 pg/mL
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Neuroscience
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of mouse Aβ1-42 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	92
	Range %	88-99
1:2	Average %	95
	Range %	85-105
1:4	Average %	96
	Range %	90-105
1:8	Average %	93
	Range %	86-100

回收率：

The recovery of mouse Aβ1-42 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	95	90-100
EDTA plasma (n=4)	93	85-96

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
1000	2.490	2.451	2.471	2.337
500	2.049	1.985	2.017	1.883
250	1.357	1.385	1.371	1.237
125	0.866	0.837	0.852	0.718
62.5	0.517	0.524	0.521	0.387
31.2	0.347	0.355	0.351	0.217
15.6	0.244	0.228	0.236	0.102
0	0.135	0.132	0.134

數(shù)據(jù)處理：

ELISA操作視頻及標(biāo)曲繪制軟件下載
貨期：

3-5 working days

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最新研究進(jìn)展：

Aβ1-42是β淀粉樣蛋白（Aβ）家族的一員，它是阿爾茨海默病（AD）病理學(xué)的主要成分。最近的研究表明，Aβ1-42的積聚是導(dǎo)致AD的主要因素之一。已經(jīng)發(fā)現(xiàn)許多抗Aβ1-42藥物，如免疫療法和β-淀粉樣蛋白藥物，這些藥物能夠清除Aβ1-42，并恢復(fù)AD患者的認(rèn)知能力。此外，一些研究還發(fā)現(xiàn)，Aβ1-42可能是癲癇的重要病理因素，這為癲癇治療提供了新的思路。

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.