Rat Thyroglobulin,TG ELISA Kit

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中文名稱：

大鼠甲狀腺球蛋白(TG)酶聯(lián)免疫試劑盒
貨號(hào)：

CSB-E08240r
規(guī)格：

96T/48T
價(jià)格：

￥3900/￥2500
促銷：
其他：

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大鼠甲狀腺球蛋白(TG)酶聯(lián)免疫試劑盒（CSB-E08240r）為競(jìng)爭(zhēng)法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的TG含量。大鼠甲狀腺球蛋白（TG）是甲狀腺濾泡細(xì)胞合成的糖蛋白，參與甲狀腺激素的合成和儲(chǔ)存。其負(fù)反饋調(diào)節(jié)機(jī)制涉及抑制甲狀腺激素合成基因表達(dá)，與促甲狀腺激素（TSH）共同調(diào)控甲狀腺功能，對(duì)甲狀腺癌的診斷和預(yù)后評(píng)估具有重要意義。試劑盒檢測(cè)范圍為10 ng/mL-160 ng/mL，適用于科研領(lǐng)域?qū)谞钕俟δ芗跋嚓P(guān)疾病的機(jī)制研究；適用于甲狀腺相關(guān)藥物的作用評(píng)估、環(huán)境毒素對(duì)甲狀腺影響的機(jī)制研究，以及甲狀腺疾病動(dòng)物模型中病理進(jìn)程的動(dòng)態(tài)監(jiān)測(cè)本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
別名：

TgThyroglobulin ELISA kit; Tg ELISA kit
縮寫：

TG
Uniprot No.：

P06882
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue Homogenates
檢測(cè)范圍：

10 ng/mL-160 ng/mL
靈敏度：

10 ng/mL
反應(yīng)時(shí)間：

1-5h
樣本體積：

50-100ul
檢測(cè)波長(zhǎng)：

450 nm
研究領(lǐng)域：

Metabolism
測(cè)定原理：

quantitative
測(cè)定方法：

Competitive

精密度：

Intra-assay Precision (Precision within an assay): CV%<15%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<15%
Three samples of known concentration were tested in twenty assays to assess.

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of rat TG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	95
	Range %	89-102
1:2	Average %	92
	Range %	86-99
1:4	Average %	95
	Range %	87-105
1:8	Average %	90
	Range %	83-102

回收率：

The recovery of rat TG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	96	89-100
EDTA plasma (n=4)	95	88-103

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml	OD1	OD2	Average
10	2.553	2.568	2.561
20	1.748	1.763	1.756
40	0.885	0.875	0.880
80	0.515	0.511	0.513
160	0.285	0.287	0.286

數(shù)據(jù)處理：

ELISA操作視頻及標(biāo)曲繪制軟件下載
貨期：

3-5 working days

引用文獻(xiàn)

The ameliorative role of germinated fenugreek and barley grains on the structure and function of offspring's tibialis muscle maternally fed on high fat diet FA Hassan Megahed,/,2024
The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile, and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats BU Khan,/,2024
A comparison of the thyroid disruption induced by decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats Wang Y, et al,Ecotoxicology and environmental safety,2019
ER stress contributes to high fat diet induced decrease of thyroglobulin and hypothyroidism Zhang X, et al,American Journal of Physiology-Endocrinology and Metabolism,2019
Altered thyroid hormone production induced by long-term exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane Yaglova N V.et al,Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry,2015
Rutin protects against aging-related metabolic dysfunction Li T. et al,Food Funct,2016
Mechanisms of Disruptive Action of Dichlorodiphenyltrichloroethane (DDT) on the Function of Thyroid Follicular Epitheliocytes. Yaglova NV. et al,Bull Exp Biol Med,2015

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功能：

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules.
相關(guān)疾病：

Defects in Tg are a cause of a form of hypothyroidism in rdw rat.
亞細(xì)胞定位：

Secreted.
蛋白家族：

Type-B carboxylesterase/lipase family
組織特異性：

Specifically expressed in the thyroid gland.
數(shù)據(jù)庫(kù)鏈接：

STRING: 10116.ENSRNOP00000009241

UniGene: Rn.10429

Rat Thyroglobulin,TG ELISA Kit

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