Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.

1. an Ntv-a transgenic rat colony was established and used to study glial brain tumors driven by two well-characterized oncogenic gene transformations, PDGFA overexpression and p53 depletion. Combined PDGFA and p53 alterations resulted in large, heterogeneous tumors in all affected animals PMID: 28358926
2. Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation. PMID: 26262503
3. expression altered in experimental Necrotizing enterocolitis PMID: 25899145
4. PDGF regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1. PMID: 26032503
5. Replacing heregulin, PDGF-AA and bFGF with T3 for 6 days resulted in repression of O4, O1, Olig2 and PDGFR-a PMID: 25200619
6. observations indicated that PDGF can contribute to the development of cardiac interstitial fibrosis in the noninfarcted myocardium, but does not alter scar formation in the infarcted myocardium. PMID: 25148874
7. We detected the expression and levels of PDGF-AA, bFGF and IGF-1 in neuroblastoma cells and in conditioned media which stimulated proliferation of oligodendrocyte precursor cells. PMID: 22922759
8. PDGF-AA contained in B104 neuroblastoma cells is a key regulating molecule that instructs oligodendrocyte differentiation from embryonic stem cells through activation of Erk, PI3K, and p38 signal pathway in vitro. PMID: 21953009
9. Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs PMID: 21559360
10. Paraquat-treated rats showed enhanced gene expression of growth factors such as platelet-derived growth factor-A and insulin-like growth factor-1 at 21 days and transforming growth factor-beta 1 at 14 days. PMID: 20498031
11. The influence of physical exercise on the generation of PDGF-AA, in adipose tissue PMID: 20972576
12. NF-kappaB modulates the expression of PDGF-a and PDGF-B in rat retina induced by IL-1beta. PMID: 17442164
13. LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasing PDGF-Ralpha on pulmonary fibroblasts PMID: 19738159
14. the PDGF/PDGF receptor system is expressed in pituitary folliculostellate cells and is involved in VEGF regulation. PMID: 19373754
15. platelet-derived growth factor-A and -B are stimulated by sphingosine 1-phosphate through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5 PMID: 14711826
16. NHERF2 stimulates PDGF-induced proliferation by increasing PI-3-kinase/Akt, MEKindependent ERK, and Src family kinase-mediated signaling pathways PMID: 15115658
17. analysis of expression of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells PMID: 16039137
18. the significance of the first expression of PDGF-A in the Leydig progenitor cells may be associated with inducing cell proliferation and migration of this cell away from the peritubular region during Leydig cell differentiation PMID: 16977580
19. These results suggest that the neurotrophic effect of platelet-derived growth factor is mediated in part via upregulation of the expression and release of secreted amyloid precursor protein alpha. PMID: 17632272
20. the inflammatory response associated with spinal cord injury in cutaneous wound healing resulted in no change in expression of platelet-derived growth factor-A at the wound site in injured rats compared to the control group PMID: 18428026
21. PDGF-A may act to mobilize oligodendrocyte progenitor cells that then respond to distinct directional signals to distribute appropriately within the CNS. PMID: 18512152
22. PTH-induced bone marrow fibrosis is mediated by PDGF-A via a phosphoinositide 3-kinase-dependent signaling pathway. PMID: 18635661
23. PDGFR (platelet derived growth factor receptor)-alpha mRNA Is Upregulated in Acutely-Rejecting, and PDGF-A and PDGF-C mRNAis upregulated in Chronically-Rejecting Cardiac Allografts PMID: 19213942
24. Report effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes. PMID: 19691150

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Secreted.

PDGF/VEGF growth factor family

KEGG: rno:25266

STRING: 10116.ENSRNOP00000001775

UniGene: Rn.10999