Mouse macrophage inflammatory protein 3β,MIP-3β ELISA kit

Mouse macrophage inflammatory protein 3β,MIP-3β ELISA kit

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中文名稱：

小鼠巨噬細胞炎性蛋白3β(MIP-3β/ELC/CCL19)酶聯免疫試劑盒
貨號：

CSB-E04671m
規格：

96T/48T
價格：

￥3200/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產品描述：

小鼠巨噬細胞炎性蛋白3β(MIP-3β/ELC/CCL19)酶聯免疫試劑盒（CSB-E04671m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL19含量。CCL19，即趨化因子CCL19，是一種小分子蛋白，主要在樹突狀細胞、T細胞和多種腫瘤細胞上表達。它通過與其受體CCR7結合，在免疫系統中發揮重要作用，如趨化樹突狀細胞和T細胞浸潤腫瘤，介導免疫細胞釋放細胞因子，抑制腫瘤增殖、遷移和侵襲，是腫瘤免疫治療的重要靶點。試劑盒檢測范圍為39 pg/ml- 2500 pg/ml，靈敏度為9.75 pg/ml。科研人員可通過開展免疫性疾病機制研究，如自身免疫模型、感染性疾病或腫瘤微環境相關實驗，尤其適用于評估淋巴結、脾臟等免疫器官中趨化因子的調控規律；寬泛的線性范圍特別適用于動態監測炎癥模型中趨化因子的表達變化本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Ccl19 ELISA Kit; Elc ELISA Kit; Scya19 ELISA Kit; C-C motif chemokine 19 ELISA Kit; Epstein-Barr virus-induced molecule 1 ligand chemokine ELISA Kit; EBI1 ligand chemokine ELISA Kit; ELC ELISA Kit; Small-inducible cytokine A19 ELISA Kit
縮寫：

CCL19
Uniprot No.：

O70460
種屬：

Mus musculus (Mouse)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

39 pg/ml - 2500 pg/ml
靈敏度：

9.75 pg/ml
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of mouse MIP-3β in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

	Sample	Serum(n=4)
1:1	Average %	96
	Range %	93-99
1:2	Average %	104
	Range %	100-107
1:4	Average %	85
	Range %	81-89
1:8	Average %	98
	Range %	94-103

回收率：

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml

OD1

OD2

Average

Corrected

2500

2.830

2.786

2.808

2.629

1250

2.286

2.301

2.294

2.115

625

1.656

1.672

1.664

1.485

312.5

1.007

1.069

1.038

0.859

156.25

0.683

0.698

0.691

0.512

0.457

0.438

0.448

0.269

0.321

0.331

0.326

0.147

0.178

0.179

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Ginsenoside CK potentiates SIRT1 to alleviate lupus nephritis through compensating for XBP1-mediated endoplasmic reticulum stress in plasma cells Z Song, Y Li, S Xu, S Qian, W Xu, L Xu, F Tian,Journal of Pharmaceutical Analysis,2025
Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner Z Song,Journal of ginseng research,2024

功能：

Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
亞細胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
組織特異性：

Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.
數據庫鏈接：

KEGG: mmu:100039053

STRING: 10090.ENSMUSP00000137353

UniGene: Mm.426373

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.